Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation

AMPK activation has been suggested as treatment for obesity and its complications. Here the authors show that the ubiquitin ligase MKRN1 binds to AMPK and mediates its ubiquitination and degradation. Loss of MKRN1 leads to AMPK activation, increased glucose consumption and decreased lipid accumulati...

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Autores principales:	Min-Sik Lee, Hyun-Ji Han, Su Yeon Han, Il Young Kim, Sehyun Chae, Choong-Sil Lee, Sung Eun Kim, Seul Gi Yoon, Jun-Won Park, Jung-Hoon Kim, Soyeon Shin, Manhyung Jeong, Aram Ko, Ho-Young Lee, Kyoung-Jin Oh, Yun-Hee Lee, Kwang-Hee Bae, Seung-Hoi Koo, Jea-woo Kim, Je Kyung Seong, Daehee Hwang, Jaewhan Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/808f9e7ecce2423aa60cf5a7715788c6
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spelling	oai:doaj.org-article:808f9e7ecce2423aa60cf5a7715788c62021-12-02T14:40:09ZLoss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation10.1038/s41467-018-05721-42041-1723https://doaj.org/article/808f9e7ecce2423aa60cf5a7715788c62018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05721-4https://doaj.org/toc/2041-1723AMPK activation has been suggested as treatment for obesity and its complications. Here the authors show that the ubiquitin ligase MKRN1 binds to AMPK and mediates its ubiquitination and degradation. Loss of MKRN1 leads to AMPK activation, increased glucose consumption and decreased lipid accumulation.Min-Sik LeeHyun-Ji HanSu Yeon HanIl Young KimSehyun ChaeChoong-Sil LeeSung Eun KimSeul Gi YoonJun-Won ParkJung-Hoon KimSoyeon ShinManhyung JeongAram KoHo-Young LeeKyoung-Jin OhYun-Hee LeeKwang-Hee BaeSeung-Hoi KooJea-woo KimJe Kyung SeongDaehee HwangJaewhan SongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Min-Sik Lee Hyun-Ji Han Su Yeon Han Il Young Kim Sehyun Chae Choong-Sil Lee Sung Eun Kim Seul Gi Yoon Jun-Won Park Jung-Hoon Kim Soyeon Shin Manhyung Jeong Aram Ko Ho-Young Lee Kyoung-Jin Oh Yun-Hee Lee Kwang-Hee Bae Seung-Hoi Koo Jea-woo Kim Je Kyung Seong Daehee Hwang Jaewhan Song Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
description	AMPK activation has been suggested as treatment for obesity and its complications. Here the authors show that the ubiquitin ligase MKRN1 binds to AMPK and mediates its ubiquitination and degradation. Loss of MKRN1 leads to AMPK activation, increased glucose consumption and decreased lipid accumulation.
format	article
author	Min-Sik Lee Hyun-Ji Han Su Yeon Han Il Young Kim Sehyun Chae Choong-Sil Lee Sung Eun Kim Seul Gi Yoon Jun-Won Park Jung-Hoon Kim Soyeon Shin Manhyung Jeong Aram Ko Ho-Young Lee Kyoung-Jin Oh Yun-Hee Lee Kwang-Hee Bae Seung-Hoi Koo Jea-woo Kim Je Kyung Seong Daehee Hwang Jaewhan Song
author_facet	Min-Sik Lee Hyun-Ji Han Su Yeon Han Il Young Kim Sehyun Chae Choong-Sil Lee Sung Eun Kim Seul Gi Yoon Jun-Won Park Jung-Hoon Kim Soyeon Shin Manhyung Jeong Aram Ko Ho-Young Lee Kyoung-Jin Oh Yun-Hee Lee Kwang-Hee Bae Seung-Hoi Koo Jea-woo Kim Je Kyung Seong Daehee Hwang Jaewhan Song
author_sort	Min-Sik Lee
title	Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
title_short	Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
title_full	Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
title_fullStr	Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
title_full_unstemmed	Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
title_sort	loss of the e3 ubiquitin ligase mkrn1 represses diet-induced metabolic syndrome through ampk activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/808f9e7ecce2423aa60cf5a7715788c6
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Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation

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