Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs

In a lupus environment, basophils accumulate in secondary lymphoid organs where they affect pathogenesis by stimulating autoantibody production. Here the authors show this accumulation is driven by PGD2-induced CXCR4 surface expression and trafficking of basophils.

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Autores principales:	Christophe Pellefigues, Barbara Dema, Yasmine Lamri, Fanny Saidoune, Nathalie Chavarot, Charlotte Lohéac, Emeline Pacreau, Michael Dussiot, Caroline Bidault, Florian Marquet, Mathieu Jablonski, Jonathan M. Chemouny, Fanny Jouan, Antoine Dossier, Marie-Paule Chauveheid, Delphine Gobert, Thomas Papo, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80954cdc9d4244429cf721f1490b4ce5
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spelling	oai:doaj.org-article:80954cdc9d4244429cf721f1490b4ce52021-12-02T17:31:42ZProstaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs10.1038/s41467-018-03129-82041-1723https://doaj.org/article/80954cdc9d4244429cf721f1490b4ce52018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03129-8https://doaj.org/toc/2041-1723In a lupus environment, basophils accumulate in secondary lymphoid organs where they affect pathogenesis by stimulating autoantibody production. Here the authors show this accumulation is driven by PGD2-induced CXCR4 surface expression and trafficking of basophils.Christophe PellefiguesBarbara DemaYasmine LamriFanny SaidouneNathalie ChavarotCharlotte LohéacEmeline PacreauMichael DussiotCaroline BidaultFlorian MarquetMathieu JablonskiJonathan M. ChemounyFanny JouanAntoine DossierMarie-Paule ChauveheidDelphine GobertThomas PapoHajime KarasuyamaKarim SacréEric DaugasNicolas CharlesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christophe Pellefigues Barbara Dema Yasmine Lamri Fanny Saidoune Nathalie Chavarot Charlotte Lohéac Emeline Pacreau Michael Dussiot Caroline Bidault Florian Marquet Mathieu Jablonski Jonathan M. Chemouny Fanny Jouan Antoine Dossier Marie-Paule Chauveheid Delphine Gobert Thomas Papo Hajime Karasuyama Karim Sacré Eric Daugas Nicolas Charles Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs
description	In a lupus environment, basophils accumulate in secondary lymphoid organs where they affect pathogenesis by stimulating autoantibody production. Here the authors show this accumulation is driven by PGD2-induced CXCR4 surface expression and trafficking of basophils.
format	article
author	Christophe Pellefigues Barbara Dema Yasmine Lamri Fanny Saidoune Nathalie Chavarot Charlotte Lohéac Emeline Pacreau Michael Dussiot Caroline Bidault Florian Marquet Mathieu Jablonski Jonathan M. Chemouny Fanny Jouan Antoine Dossier Marie-Paule Chauveheid Delphine Gobert Thomas Papo Hajime Karasuyama Karim Sacré Eric Daugas Nicolas Charles
author_facet	Christophe Pellefigues Barbara Dema Yasmine Lamri Fanny Saidoune Nathalie Chavarot Charlotte Lohéac Emeline Pacreau Michael Dussiot Caroline Bidault Florian Marquet Mathieu Jablonski Jonathan M. Chemouny Fanny Jouan Antoine Dossier Marie-Paule Chauveheid Delphine Gobert Thomas Papo Hajime Karasuyama Karim Sacré Eric Daugas Nicolas Charles
author_sort	Christophe Pellefigues
title	Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs
title_short	Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs
title_full	Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs
title_fullStr	Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs
title_full_unstemmed	Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs
title_sort	prostaglandin d2 amplifies lupus disease through basophil accumulation in lymphoid organs
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/80954cdc9d4244429cf721f1490b4ce5
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Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs

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