Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

Cell cycle and replication need to be tightly regulated to ensure genome stability in mammalian cells. Here the authors provide a link between chromatin structure and DNA replication regulation by showing that chromatin compaction limits replication licensing thereby promoting genome integrity.

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Autores principales:	Muhammad Shoaib, David Walter, Peter J. Gillespie, Fanny Izard, Birthe Fahrenkrog, David Lleres, Mads Lerdrup, Jens Vilstrup Johansen, Klaus Hansen, Eric Julien, J. Julian Blow, Claus S. Sørensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8099256713994c5ea367ade824604648
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spelling	oai:doaj.org-article:8099256713994c5ea367ade8246046482021-12-02T15:34:50ZHistone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing10.1038/s41467-018-06066-82041-1723https://doaj.org/article/8099256713994c5ea367ade8246046482018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06066-8https://doaj.org/toc/2041-1723Cell cycle and replication need to be tightly regulated to ensure genome stability in mammalian cells. Here the authors provide a link between chromatin structure and DNA replication regulation by showing that chromatin compaction limits replication licensing thereby promoting genome integrity.Muhammad ShoaibDavid WalterPeter J. GillespieFanny IzardBirthe FahrenkrogDavid LleresMads LerdrupJens Vilstrup JohansenKlaus HansenEric JulienJ. Julian BlowClaus S. SørensenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Muhammad Shoaib David Walter Peter J. Gillespie Fanny Izard Birthe Fahrenkrog David Lleres Mads Lerdrup Jens Vilstrup Johansen Klaus Hansen Eric Julien J. Julian Blow Claus S. Sørensen Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
description	Cell cycle and replication need to be tightly regulated to ensure genome stability in mammalian cells. Here the authors provide a link between chromatin structure and DNA replication regulation by showing that chromatin compaction limits replication licensing thereby promoting genome integrity.
format	article
author	Muhammad Shoaib David Walter Peter J. Gillespie Fanny Izard Birthe Fahrenkrog David Lleres Mads Lerdrup Jens Vilstrup Johansen Klaus Hansen Eric Julien J. Julian Blow Claus S. Sørensen
author_facet	Muhammad Shoaib David Walter Peter J. Gillespie Fanny Izard Birthe Fahrenkrog David Lleres Mads Lerdrup Jens Vilstrup Johansen Klaus Hansen Eric Julien J. Julian Blow Claus S. Sørensen
author_sort	Muhammad Shoaib
title	Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
title_short	Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
title_full	Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
title_fullStr	Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
title_full_unstemmed	Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
title_sort	histone h4k20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting dna replication licensing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8099256713994c5ea367ade824604648
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Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

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