Psychiatric Comorbidities in 1p36 Deletion Syndrome and Their Treatment—A Case Report

1p36 deletion syndrome represents the most common terminal deletion observed in humans. Major clinical findings comprise developmental delay/intellectual disability, poor or absent expressive language, congenital central muscular hypotonia, brain anomalies, brachydactyly/camptodactyly, short feet, a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Wolfgang Briegel
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	1p36 deletion syndrome oppositional-defiant disorder attention deficit/hyperactivity disorder parent-child interaction therapy (PCIT) melatonin methylphenidate Medicine R
Acceso en línea:	https://doaj.org/article/809d31dd2c4d41b6959c35a932164c90
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:809d31dd2c4d41b6959c35a932164c90
record_format	dspace
spelling	oai:doaj.org-article:809d31dd2c4d41b6959c35a932164c902021-11-25T17:50:46ZPsychiatric Comorbidities in 1p36 Deletion Syndrome and Their Treatment—A Case Report10.3390/ijerph1822120641660-46011661-7827https://doaj.org/article/809d31dd2c4d41b6959c35a932164c902021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/12064https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-46011p36 deletion syndrome represents the most common terminal deletion observed in humans. Major clinical findings comprise developmental delay/intellectual disability, poor or absent expressive language, congenital central muscular hypotonia, brain anomalies, brachydactyly/camptodactyly, short feet, and characteristic facial features like straight eyebrows, deep-set eyes, and midface hypoplasia. So far, there is very limited knowledge about comorbid psychiatric disorders and their effective treatment in this special population. To fill this gap, this case report presents an initially four-year-old girl with 1p36.33–1p36.32 deletion, moderate intellectual disability, insomnia, oppositional-defiant disorder and attention deficit/hyperactivity disorder covering a period of time of about 1.5 years comprising initial psychological/psychiatric assessment, subsequent day clinic/outpatient treatment (amongst others including off-label use of melatonin and methylphenidate as well as parent-child interaction therapy) and follow-up assessment. Follow-up results indicated good efficacy of melatonin and methylphenidate medication without any adverse effects. Multidisciplinarity in diagnosis and treatment are mandatory to meet needs of patients with complex genetic disorders like 1p36 deletion syndrome. Off-label use of melatonin (for insomnia) and methylphenidate (for attention deficit/hyperactivity disorder) should be considered in young children with 1p36 deletion syndrome if behavioral interventions are not sufficient.Wolfgang BriegelMDPI AGarticle1p36 deletion syndromeoppositional-defiant disorderattention deficit/hyperactivity disorderparent-child interaction therapy (PCIT)melatoninmethylphenidateMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 12064, p 12064 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	1p36 deletion syndrome oppositional-defiant disorder attention deficit/hyperactivity disorder parent-child interaction therapy (PCIT) melatonin methylphenidate Medicine R
spellingShingle	1p36 deletion syndrome oppositional-defiant disorder attention deficit/hyperactivity disorder parent-child interaction therapy (PCIT) melatonin methylphenidate Medicine R Wolfgang Briegel Psychiatric Comorbidities in 1p36 Deletion Syndrome and Their Treatment—A Case Report
description	1p36 deletion syndrome represents the most common terminal deletion observed in humans. Major clinical findings comprise developmental delay/intellectual disability, poor or absent expressive language, congenital central muscular hypotonia, brain anomalies, brachydactyly/camptodactyly, short feet, and characteristic facial features like straight eyebrows, deep-set eyes, and midface hypoplasia. So far, there is very limited knowledge about comorbid psychiatric disorders and their effective treatment in this special population. To fill this gap, this case report presents an initially four-year-old girl with 1p36.33–1p36.32 deletion, moderate intellectual disability, insomnia, oppositional-defiant disorder and attention deficit/hyperactivity disorder covering a period of time of about 1.5 years comprising initial psychological/psychiatric assessment, subsequent day clinic/outpatient treatment (amongst others including off-label use of melatonin and methylphenidate as well as parent-child interaction therapy) and follow-up assessment. Follow-up results indicated good efficacy of melatonin and methylphenidate medication without any adverse effects. Multidisciplinarity in diagnosis and treatment are mandatory to meet needs of patients with complex genetic disorders like 1p36 deletion syndrome. Off-label use of melatonin (for insomnia) and methylphenidate (for attention deficit/hyperactivity disorder) should be considered in young children with 1p36 deletion syndrome if behavioral interventions are not sufficient.
format	article
author	Wolfgang Briegel
author_facet	Wolfgang Briegel
author_sort	Wolfgang Briegel
title	Psychiatric Comorbidities in 1p36 Deletion Syndrome and Their Treatment—A Case Report
title_short	Psychiatric Comorbidities in 1p36 Deletion Syndrome and Their Treatment—A Case Report
title_full	Psychiatric Comorbidities in 1p36 Deletion Syndrome and Their Treatment—A Case Report
title_fullStr	Psychiatric Comorbidities in 1p36 Deletion Syndrome and Their Treatment—A Case Report
title_full_unstemmed	Psychiatric Comorbidities in 1p36 Deletion Syndrome and Their Treatment—A Case Report
title_sort	psychiatric comorbidities in 1p36 deletion syndrome and their treatment—a case report
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/809d31dd2c4d41b6959c35a932164c90
work_keys_str_mv	AT wolfgangbriegel psychiatriccomorbiditiesin1p36deletionsyndromeandtheirtreatmentacasereport
_version_	1718411930892238848

Psychiatric Comorbidities in 1p36 Deletion Syndrome and Their Treatment—A Case Report

Ejemplares similares