Association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage

Abstract The association between early glycemic change and short-term mortality in non-diabetic patients with acute intracerebral hemorrhage (ICH) is unclear. We retrospectively investigated non-diabetic patients with lobar (n = 262) and non-lobar ICH (n = 370). Each patient had a random serum gluco...

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Autores principales:	Paola Forti, Fabiola Maioli, Marco Zoli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/809f2870f68f45e0afa90d7275917ccc
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spelling	oai:doaj.org-article:809f2870f68f45e0afa90d7275917ccc2021-12-02T18:50:44ZAssociation of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage10.1038/s41598-021-95453-12045-2322https://doaj.org/article/809f2870f68f45e0afa90d7275917ccc2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95453-1https://doaj.org/toc/2045-2322Abstract The association between early glycemic change and short-term mortality in non-diabetic patients with acute intracerebral hemorrhage (ICH) is unclear. We retrospectively investigated non-diabetic patients with lobar (n = 262) and non-lobar ICH (n = 370). Each patient had a random serum glucose test on hospital admission and a fasting serum glucose test within the following 48 h. Hyperglycemia was defined as serum glucose ≥ 7.8 mmol/l. Four patterns were determined: no hyperglycemia (reference category), persistent hyperglycemia, delayed hyperglycemia, and decreasing hyperglycemia. Associations with 30-day mortality were estimated using Cox models adjusted for major features of ICH severity. Persistent hyperglycemia was associated with 30-day mortality in both lobar (HR 3.00; 95% CI 1.28–7.02) and non-lobar ICH (HR 4.95; 95% CI 2.20–11.09). In lobar ICH, 30-day mortality was also associated with delayed (HR 4.10; 95% CI 1.77–9.49) and decreasing hyperglycemia (HR 2.01, 95% CI 1.09–3.70). These findings were confirmed in Cox models using glycemic change (fasting minus random serum glucose) as a continuous variable. Our study shows that, in non-diabetic patients with ICH, early persistent hyperglycemia is an independent predictor of short-term mortality regardless of hematoma location. Moreover, in non-diabetic patients with lobar ICH, both a positive and a negative glycemic change are associated with short-term mortality.Paola FortiFabiola MaioliMarco ZoliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paola Forti Fabiola Maioli Marco Zoli Association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage
description	Abstract The association between early glycemic change and short-term mortality in non-diabetic patients with acute intracerebral hemorrhage (ICH) is unclear. We retrospectively investigated non-diabetic patients with lobar (n = 262) and non-lobar ICH (n = 370). Each patient had a random serum glucose test on hospital admission and a fasting serum glucose test within the following 48 h. Hyperglycemia was defined as serum glucose ≥ 7.8 mmol/l. Four patterns were determined: no hyperglycemia (reference category), persistent hyperglycemia, delayed hyperglycemia, and decreasing hyperglycemia. Associations with 30-day mortality were estimated using Cox models adjusted for major features of ICH severity. Persistent hyperglycemia was associated with 30-day mortality in both lobar (HR 3.00; 95% CI 1.28–7.02) and non-lobar ICH (HR 4.95; 95% CI 2.20–11.09). In lobar ICH, 30-day mortality was also associated with delayed (HR 4.10; 95% CI 1.77–9.49) and decreasing hyperglycemia (HR 2.01, 95% CI 1.09–3.70). These findings were confirmed in Cox models using glycemic change (fasting minus random serum glucose) as a continuous variable. Our study shows that, in non-diabetic patients with ICH, early persistent hyperglycemia is an independent predictor of short-term mortality regardless of hematoma location. Moreover, in non-diabetic patients with lobar ICH, both a positive and a negative glycemic change are associated with short-term mortality.
format	article
author	Paola Forti Fabiola Maioli Marco Zoli
author_facet	Paola Forti Fabiola Maioli Marco Zoli
author_sort	Paola Forti
title	Association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage
title_short	Association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage
title_full	Association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage
title_fullStr	Association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage
title_full_unstemmed	Association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage
title_sort	association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/809f2870f68f45e0afa90d7275917ccc
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Association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage

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