Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia

Chencai Wang,1 Chao-Hsiung Hsu,1,2 Zhao Li,1 Lian-Pin Hwang,2 Ying-Chih Lin,2 Pi-Tai Chou,2 Yung-Ya Lin1 1Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA; 2Department of Chemistry, National Taiwan University, Taipei, Taiwan Abstract: Magnetic resonance (MR)...

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Autores principales:	Wang C, Hsu CH, Li Z, Hwang LP, Lin YC, Chou PT, Lin YY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	nano-theranostics hyperthermia magnetic resonance magnetic nanoparticle specific loss power Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/80a3d480f2fd4fc88dccaa2bfb390c8a
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spelling	oai:doaj.org-article:80a3d480f2fd4fc88dccaa2bfb390c8a2021-12-02T05:02:15ZEffective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia1178-2013https://doaj.org/article/80a3d480f2fd4fc88dccaa2bfb390c8a2017-08-01T00:00:00Zhttps://www.dovepress.com/effective-heating-of-magnetic-nanoparticle-aggregates-for-in-vivo-nano-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chencai Wang,1 Chao-Hsiung Hsu,1,2 Zhao Li,1 Lian-Pin Hwang,2 Ying-Chih Lin,2 Pi-Tai Chou,2 Yung-Ya Lin1 1Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA; 2Department of Chemistry, National Taiwan University, Taipei, Taiwan Abstract: Magnetic resonance (MR) nano-theranostic hyperthermia uses magnetic nanoparticles to target and accumulate at the lesions and generate heat to kill lesion cells directly through hyperthermia or indirectly through thermal activation and control releasing of drugs. Preclinical and translational applications of MR nano-theranostic hyperthermia are currently limited by a few major theoretical difficulties and experimental challenges in in vivo conditions. For example, conventional models for estimating the heat generated and the optimal magnetic nanoparticle sizes for hyperthermia do not accurately reproduce reported in vivo experimental results. In this work, a revised cluster-based model was proposed to predict the specific loss power (SLP) by explicitly considering magnetic nanoparticle aggregation in in vivo conditions. By comparing with the reported experimental results of magnetite Fe3O4 and cobalt ferrite CoFe2O4 magnetic nanoparticles, it is shown that the revised cluster-based model provides a more accurate prediction of the experimental values than the conventional models that assume magnetic nanoparticles act as single units. It also provides a clear physical picture: the aggregation of magnetic nanoparticles increases the cluster magnetic anisotropy while reducing both the cluster domain magnetization and the average magnetic moment, which, in turn, shift the predicted SLP toward a smaller magnetic nanoparticle diameter with lower peak values. As a result, the heating efficiency and the SLP values are decreased. The improvement in the prediction accuracy in in vivo conditions is particularly pronounced when the magnetic nanoparticle diameter is in the range of ~10–20 nm. This happens to be an important size range for MR cancer nano-theranostics, as it exhibits the highest efficacy against both primary and metastatic tumors in vivo. Our studies show that a relatively 20%–25% smaller magnetic nanoparticle diameter should be chosen to reach the maximal heating efficiency in comparison with the optimal size predicted by previous models. Keywords: nano-theranostics, hyperthermia, magnetic resonance, magnetic nanoparticle, specific loss powerWang CHsu CHLi ZHwang LPLin YCChou PTLin YYDove Medical Pressarticlenano-theranosticshyperthermiamagnetic resonancemagnetic nanoparticlespecific loss powerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6273-6287 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	nano-theranostics hyperthermia magnetic resonance magnetic nanoparticle specific loss power Medicine (General) R5-920
spellingShingle	nano-theranostics hyperthermia magnetic resonance magnetic nanoparticle specific loss power Medicine (General) R5-920 Wang C Hsu CH Li Z Hwang LP Lin YC Chou PT Lin YY Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia
description	Chencai Wang,1 Chao-Hsiung Hsu,1,2 Zhao Li,1 Lian-Pin Hwang,2 Ying-Chih Lin,2 Pi-Tai Chou,2 Yung-Ya Lin1 1Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA; 2Department of Chemistry, National Taiwan University, Taipei, Taiwan Abstract: Magnetic resonance (MR) nano-theranostic hyperthermia uses magnetic nanoparticles to target and accumulate at the lesions and generate heat to kill lesion cells directly through hyperthermia or indirectly through thermal activation and control releasing of drugs. Preclinical and translational applications of MR nano-theranostic hyperthermia are currently limited by a few major theoretical difficulties and experimental challenges in in vivo conditions. For example, conventional models for estimating the heat generated and the optimal magnetic nanoparticle sizes for hyperthermia do not accurately reproduce reported in vivo experimental results. In this work, a revised cluster-based model was proposed to predict the specific loss power (SLP) by explicitly considering magnetic nanoparticle aggregation in in vivo conditions. By comparing with the reported experimental results of magnetite Fe3O4 and cobalt ferrite CoFe2O4 magnetic nanoparticles, it is shown that the revised cluster-based model provides a more accurate prediction of the experimental values than the conventional models that assume magnetic nanoparticles act as single units. It also provides a clear physical picture: the aggregation of magnetic nanoparticles increases the cluster magnetic anisotropy while reducing both the cluster domain magnetization and the average magnetic moment, which, in turn, shift the predicted SLP toward a smaller magnetic nanoparticle diameter with lower peak values. As a result, the heating efficiency and the SLP values are decreased. The improvement in the prediction accuracy in in vivo conditions is particularly pronounced when the magnetic nanoparticle diameter is in the range of ~10–20 nm. This happens to be an important size range for MR cancer nano-theranostics, as it exhibits the highest efficacy against both primary and metastatic tumors in vivo. Our studies show that a relatively 20%–25% smaller magnetic nanoparticle diameter should be chosen to reach the maximal heating efficiency in comparison with the optimal size predicted by previous models. Keywords: nano-theranostics, hyperthermia, magnetic resonance, magnetic nanoparticle, specific loss power
format	article
author	Wang C Hsu CH Li Z Hwang LP Lin YC Chou PT Lin YY
author_facet	Wang C Hsu CH Li Z Hwang LP Lin YC Chou PT Lin YY
author_sort	Wang C
title	Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia
title_short	Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia
title_full	Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia
title_fullStr	Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia
title_full_unstemmed	Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia
title_sort	effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/80a3d480f2fd4fc88dccaa2bfb390c8a
work_keys_str_mv	AT wangc effectiveheatingofmagneticnanoparticleaggregatesforinvivonanotheranostichyperthermia AT hsuch effectiveheatingofmagneticnanoparticleaggregatesforinvivonanotheranostichyperthermia AT liz effectiveheatingofmagneticnanoparticleaggregatesforinvivonanotheranostichyperthermia AT hwanglp effectiveheatingofmagneticnanoparticleaggregatesforinvivonanotheranostichyperthermia AT linyc effectiveheatingofmagneticnanoparticleaggregatesforinvivonanotheranostichyperthermia AT choupt effectiveheatingofmagneticnanoparticleaggregatesforinvivonanotheranostichyperthermia AT linyy effectiveheatingofmagneticnanoparticleaggregatesforinvivonanotheranostichyperthermia
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Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia

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