Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism

Gut microbial and metabolite alterations are linked to inflammatory bowel diseases pathogenesis. Here the authors identify functional microbiota signatures that correlate with disease activity by comparing patients with Crohn’s disease undergoing autologous hematopoietic stem cell transplantation wh...

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Autores principales:	Amira Metwaly, Andreas Dunkel, Nadine Waldschmitt, Abilash Chakravarthy Durai Raj, Ilias Lagkouvardos, Ana Maria Corraliza, Aida Mayorgas, Margarita Martinez-Medina, Sinah Reiter, Michael Schloter, Thomas Hofmann, Matthieu Allez, Julian Panes, Azucena Salas, Dirk Haller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80a8a0456f1b494a8e06f154f92dc470
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spelling	oai:doaj.org-article:80a8a0456f1b494a8e06f154f92dc4702021-12-02T18:53:15ZIntegrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism10.1038/s41467-020-17956-12041-1723https://doaj.org/article/80a8a0456f1b494a8e06f154f92dc4702020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17956-1https://doaj.org/toc/2041-1723Gut microbial and metabolite alterations are linked to inflammatory bowel diseases pathogenesis. Here the authors identify functional microbiota signatures that correlate with disease activity by comparing patients with Crohn’s disease undergoing autologous hematopoietic stem cell transplantation who either did not respond to therapy, experienced relapse after remission or maintained remission, and show that these microbial signatures recapitulate disease activity when transferred to mice.Amira MetwalyAndreas DunkelNadine WaldschmittAbilash Chakravarthy Durai RajIlias LagkouvardosAna Maria CorralizaAida MayorgasMargarita Martinez-MedinaSinah ReiterMichael SchloterThomas HofmannMatthieu AllezJulian PanesAzucena SalasDirk HallerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amira Metwaly Andreas Dunkel Nadine Waldschmitt Abilash Chakravarthy Durai Raj Ilias Lagkouvardos Ana Maria Corraliza Aida Mayorgas Margarita Martinez-Medina Sinah Reiter Michael Schloter Thomas Hofmann Matthieu Allez Julian Panes Azucena Salas Dirk Haller Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism
description	Gut microbial and metabolite alterations are linked to inflammatory bowel diseases pathogenesis. Here the authors identify functional microbiota signatures that correlate with disease activity by comparing patients with Crohn’s disease undergoing autologous hematopoietic stem cell transplantation who either did not respond to therapy, experienced relapse after remission or maintained remission, and show that these microbial signatures recapitulate disease activity when transferred to mice.
format	article
author	Amira Metwaly Andreas Dunkel Nadine Waldschmitt Abilash Chakravarthy Durai Raj Ilias Lagkouvardos Ana Maria Corraliza Aida Mayorgas Margarita Martinez-Medina Sinah Reiter Michael Schloter Thomas Hofmann Matthieu Allez Julian Panes Azucena Salas Dirk Haller
author_facet	Amira Metwaly Andreas Dunkel Nadine Waldschmitt Abilash Chakravarthy Durai Raj Ilias Lagkouvardos Ana Maria Corraliza Aida Mayorgas Margarita Martinez-Medina Sinah Reiter Michael Schloter Thomas Hofmann Matthieu Allez Julian Panes Azucena Salas Dirk Haller
author_sort	Amira Metwaly
title	Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism
title_short	Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism
title_full	Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism
title_fullStr	Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism
title_full_unstemmed	Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism
title_sort	integrated microbiota and metabolite profiles link crohn’s disease to sulfur metabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/80a8a0456f1b494a8e06f154f92dc470
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Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism

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