Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity

Cancer cells can actively engage in overcoming microenvironmental constraints such as tissue stiffness through adapting their shapes; however it is unclear how microenvironmental cells shape cancer nuclear morphology in human tumors in situ. Here the authors merge machine learning, digital pathology...

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Autores principales:	Andreas Heindl, Adnan Mujahid Khan, Daniel Nava Rodrigues, Katherine Eason, Anguraj Sadanandam, Cecilia Orbegoso, Marco Punta, Andrea Sottoriva, Stefano Lise, Susana Banerjee, Yinyin Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80aafabf129a42f2a86063973bcb2266
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spelling	oai:doaj.org-article:80aafabf129a42f2a86063973bcb22662021-12-02T17:31:29ZMicroenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity10.1038/s41467-018-06130-32041-1723https://doaj.org/article/80aafabf129a42f2a86063973bcb22662018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06130-3https://doaj.org/toc/2041-1723Cancer cells can actively engage in overcoming microenvironmental constraints such as tissue stiffness through adapting their shapes; however it is unclear how microenvironmental cells shape cancer nuclear morphology in human tumors in situ. Here the authors merge machine learning, digital pathology and spatial statistics to study this issue; furthermore the authors identify decreased immune infiltration in the surrounding of diversified cancer cells in a subset of ovarian tumors.Andreas HeindlAdnan Mujahid KhanDaniel Nava RodriguesKatherine EasonAnguraj SadanandamCecilia OrbegosoMarco PuntaAndrea SottorivaStefano LiseSusana BanerjeeYinyin YuanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andreas Heindl Adnan Mujahid Khan Daniel Nava Rodrigues Katherine Eason Anguraj Sadanandam Cecilia Orbegoso Marco Punta Andrea Sottoriva Stefano Lise Susana Banerjee Yinyin Yuan Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity
description	Cancer cells can actively engage in overcoming microenvironmental constraints such as tissue stiffness through adapting their shapes; however it is unclear how microenvironmental cells shape cancer nuclear morphology in human tumors in situ. Here the authors merge machine learning, digital pathology and spatial statistics to study this issue; furthermore the authors identify decreased immune infiltration in the surrounding of diversified cancer cells in a subset of ovarian tumors.
format	article
author	Andreas Heindl Adnan Mujahid Khan Daniel Nava Rodrigues Katherine Eason Anguraj Sadanandam Cecilia Orbegoso Marco Punta Andrea Sottoriva Stefano Lise Susana Banerjee Yinyin Yuan
author_facet	Andreas Heindl Adnan Mujahid Khan Daniel Nava Rodrigues Katherine Eason Anguraj Sadanandam Cecilia Orbegoso Marco Punta Andrea Sottoriva Stefano Lise Susana Banerjee Yinyin Yuan
author_sort	Andreas Heindl
title	Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity
title_short	Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity
title_full	Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity
title_fullStr	Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity
title_full_unstemmed	Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity
title_sort	microenvironmental niche divergence shapes brca1-dysregulated ovarian cancer morphological plasticity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/80aafabf129a42f2a86063973bcb2266
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Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity

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