Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity

Cancer cells can actively engage in overcoming microenvironmental constraints such as tissue stiffness through adapting their shapes; however it is unclear how microenvironmental cells shape cancer nuclear morphology in human tumors in situ. Here the authors merge machine learning, digital pathology...

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Bibliographic Details
Main Authors: Andreas Heindl, Adnan Mujahid Khan, Daniel Nava Rodrigues, Katherine Eason, Anguraj Sadanandam, Cecilia Orbegoso, Marco Punta, Andrea Sottoriva, Stefano Lise, Susana Banerjee, Yinyin Yuan
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/80aafabf129a42f2a86063973bcb2266
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