Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles

Ribonucleoprotein (RNP) granules are responsible for mRNA transport and local translation required for neuronal and oocyte maturation. Here the authors show that loss of the Drosophila Ub ligase Hecw enlarges RNP granules, leads to a liquid to gel-like transition, and results in defective oogenesis...

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Autores principales:	Valentina Fajner, Fabio Giavazzi, Simona Sala, Amanda Oldani, Emanuele Martini, Francesco Napoletano, Dario Parazzoli, Giuliana Cesare, Roberto Cerbino, Elena Maspero, Thomas Vaccari, Simona Polo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80abb9b6aba7465aa4f6053e0a5e349f
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spelling	oai:doaj.org-article:80abb9b6aba7465aa4f6053e0a5e349f2021-12-02T18:02:32ZHecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles10.1038/s41467-021-25809-82041-1723https://doaj.org/article/80abb9b6aba7465aa4f6053e0a5e349f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25809-8https://doaj.org/toc/2041-1723Ribonucleoprotein (RNP) granules are responsible for mRNA transport and local translation required for neuronal and oocyte maturation. Here the authors show that loss of the Drosophila Ub ligase Hecw enlarges RNP granules, leads to a liquid to gel-like transition, and results in defective oogenesis and neuronal loss.Valentina FajnerFabio GiavazziSimona SalaAmanda OldaniEmanuele MartiniFrancesco NapoletanoDario ParazzoliGiuliana CesareRoberto CerbinoElena MasperoThomas VaccariSimona PoloNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valentina Fajner Fabio Giavazzi Simona Sala Amanda Oldani Emanuele Martini Francesco Napoletano Dario Parazzoli Giuliana Cesare Roberto Cerbino Elena Maspero Thomas Vaccari Simona Polo Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
description	Ribonucleoprotein (RNP) granules are responsible for mRNA transport and local translation required for neuronal and oocyte maturation. Here the authors show that loss of the Drosophila Ub ligase Hecw enlarges RNP granules, leads to a liquid to gel-like transition, and results in defective oogenesis and neuronal loss.
format	article
author	Valentina Fajner Fabio Giavazzi Simona Sala Amanda Oldani Emanuele Martini Francesco Napoletano Dario Parazzoli Giuliana Cesare Roberto Cerbino Elena Maspero Thomas Vaccari Simona Polo
author_facet	Valentina Fajner Fabio Giavazzi Simona Sala Amanda Oldani Emanuele Martini Francesco Napoletano Dario Parazzoli Giuliana Cesare Roberto Cerbino Elena Maspero Thomas Vaccari Simona Polo
author_sort	Valentina Fajner
title	Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
title_short	Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
title_full	Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
title_fullStr	Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
title_full_unstemmed	Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
title_sort	hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/80abb9b6aba7465aa4f6053e0a5e349f
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Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles

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