Risk factors for early and late recurrence in hepatocellular carcinoma after liver transplantation

Background: Risk factors of early and late recurrence in hepatocellular carcinoma (HCC) after liver transplantation (LT) remain unclear. Aim: To identify factors that affect, both early and late recurrence in this setting. Methods: We retrospectively analyzed outcomes of 220 patients with HCC who re...

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Autores principales:	Fan Hsiu-Lung, Hsieh Chung-Bao, Kuo Shih-Ming, Chen Teng-Wei
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	hepatocellular carcinoma risk factors liver transplantation recurrence Medicine R Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Acceso en línea:	https://doaj.org/article/80ac0b35d489462893fe05abfc8bc11b
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spelling	oai:doaj.org-article:80ac0b35d489462893fe05abfc8bc11b2021-11-12T10:24:36ZRisk factors for early and late recurrence in hepatocellular carcinoma after liver transplantation1011-456410.4103/jmedsci.jmedsci_160_20https://doaj.org/article/80ac0b35d489462893fe05abfc8bc11b2021-01-01T00:00:00Zhttp://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2021;volume=41;issue=6;spage=273;epage=279;aulast=Hsiu-Lunghttps://doaj.org/toc/1011-4564Background: Risk factors of early and late recurrence in hepatocellular carcinoma (HCC) after liver transplantation (LT) remain unclear. Aim: To identify factors that affect, both early and late recurrence in this setting. Methods: We retrospectively analyzed outcomes of 220 patients with HCC who received LT. Two patients who underwent re-transplantation were excluded. Early, late, and very late recurrence were defined as recurrence in the 1st year, 1–5 years, and >5 years after LT, respectively. Kaplan–Meier survival curves were generated, and log-rank tests were performed to compare survival between these groups. Univariate and multivariate Cox proportional-hazard models for risks of early and late recurrence were established. Results: Twenty and 19 patients experienced HCC recurrence in the 1st year and between 1 and 5 years, respectively, after undergoing LT. The groups differed significantly in cumulative postrecurrence survival rate. The hazard ratio of early recurrence for tumor size >3 cm was 1.766 (P = 0.046) and that for tumor number >3 was 1.929 (P = 0.027). Alpha-fetoprotein >20 ng/mL was a predictor of early recurrence in multivariate analysis (P = 0.077). The hazard ratio of late recurrence for HCC with microvascular invasion was 1.891 (P = 0.047). Conclusion: The recurrence rate of HCC was high in the 1st year after LT. Patients with early recurrence had a poorer survival rate than those with late recurrence. Tumor size >3 cm and tumor number >3 were risk factors of early recurrence. Microvascular invasion was a risk factor for late recurrence. Close individual surveillance is needed in patients with these risk factors.Fan Hsiu-LungHsieh Chung-BaoKuo Shih-MingChen Teng-WeiWolters Kluwer Medknow Publicationsarticlehepatocellular carcinomarisk factorsliver transplantationrecurrenceMedicineRMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENJournal of Medical Sciences, Vol 41, Iss 6, Pp 273-279 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma risk factors liver transplantation recurrence Medicine R Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
spellingShingle	hepatocellular carcinoma risk factors liver transplantation recurrence Medicine R Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Fan Hsiu-Lung Hsieh Chung-Bao Kuo Shih-Ming Chen Teng-Wei Risk factors for early and late recurrence in hepatocellular carcinoma after liver transplantation
description	Background: Risk factors of early and late recurrence in hepatocellular carcinoma (HCC) after liver transplantation (LT) remain unclear. Aim: To identify factors that affect, both early and late recurrence in this setting. Methods: We retrospectively analyzed outcomes of 220 patients with HCC who received LT. Two patients who underwent re-transplantation were excluded. Early, late, and very late recurrence were defined as recurrence in the 1st year, 1–5 years, and >5 years after LT, respectively. Kaplan–Meier survival curves were generated, and log-rank tests were performed to compare survival between these groups. Univariate and multivariate Cox proportional-hazard models for risks of early and late recurrence were established. Results: Twenty and 19 patients experienced HCC recurrence in the 1st year and between 1 and 5 years, respectively, after undergoing LT. The groups differed significantly in cumulative postrecurrence survival rate. The hazard ratio of early recurrence for tumor size >3 cm was 1.766 (P = 0.046) and that for tumor number >3 was 1.929 (P = 0.027). Alpha-fetoprotein >20 ng/mL was a predictor of early recurrence in multivariate analysis (P = 0.077). The hazard ratio of late recurrence for HCC with microvascular invasion was 1.891 (P = 0.047). Conclusion: The recurrence rate of HCC was high in the 1st year after LT. Patients with early recurrence had a poorer survival rate than those with late recurrence. Tumor size >3 cm and tumor number >3 were risk factors of early recurrence. Microvascular invasion was a risk factor for late recurrence. Close individual surveillance is needed in patients with these risk factors.
format	article
author	Fan Hsiu-Lung Hsieh Chung-Bao Kuo Shih-Ming Chen Teng-Wei
author_facet	Fan Hsiu-Lung Hsieh Chung-Bao Kuo Shih-Ming Chen Teng-Wei
author_sort	Fan Hsiu-Lung
title	Risk factors for early and late recurrence in hepatocellular carcinoma after liver transplantation
title_short	Risk factors for early and late recurrence in hepatocellular carcinoma after liver transplantation
title_full	Risk factors for early and late recurrence in hepatocellular carcinoma after liver transplantation
title_fullStr	Risk factors for early and late recurrence in hepatocellular carcinoma after liver transplantation
title_full_unstemmed	Risk factors for early and late recurrence in hepatocellular carcinoma after liver transplantation
title_sort	risk factors for early and late recurrence in hepatocellular carcinoma after liver transplantation
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/80ac0b35d489462893fe05abfc8bc11b
work_keys_str_mv	AT fanhsiulung riskfactorsforearlyandlaterecurrenceinhepatocellularcarcinomaafterlivertransplantation AT hsiehchungbao riskfactorsforearlyandlaterecurrenceinhepatocellularcarcinomaafterlivertransplantation AT kuoshihming riskfactorsforearlyandlaterecurrenceinhepatocellularcarcinomaafterlivertransplantation AT chentengwei riskfactorsforearlyandlaterecurrenceinhepatocellularcarcinomaafterlivertransplantation
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Risk factors for early and late recurrence in hepatocellular carcinoma after liver transplantation

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