Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression

Disrupted dopamine neuron firing is thought to contribute to cognitive dysfunction in psychiatric disorders. Here the authors show that mice overexpressing D2R in the striatum, commonly seen in schizophrenia, are also impaired in recruitment of dopamine neurons during working memory performance.

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Autores principales:	Sevil Duvarci, Eleanor H. Simpson, Gaby Schneider, Eric R. Kandel, Jochen Roeper, Torfi Sigurdsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80af5b334ef94206b731e0310e38cc3d
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spelling	oai:doaj.org-article:80af5b334ef94206b731e0310e38cc3d2021-12-02T16:50:05ZImpaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression10.1038/s41467-018-05214-42041-1723https://doaj.org/article/80af5b334ef94206b731e0310e38cc3d2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05214-4https://doaj.org/toc/2041-1723Disrupted dopamine neuron firing is thought to contribute to cognitive dysfunction in psychiatric disorders. Here the authors show that mice overexpressing D2R in the striatum, commonly seen in schizophrenia, are also impaired in recruitment of dopamine neurons during working memory performance.Sevil DuvarciEleanor H. SimpsonGaby SchneiderEric R. KandelJochen RoeperTorfi SigurdssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sevil Duvarci Eleanor H. Simpson Gaby Schneider Eric R. Kandel Jochen Roeper Torfi Sigurdsson Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression
description	Disrupted dopamine neuron firing is thought to contribute to cognitive dysfunction in psychiatric disorders. Here the authors show that mice overexpressing D2R in the striatum, commonly seen in schizophrenia, are also impaired in recruitment of dopamine neurons during working memory performance.
format	article
author	Sevil Duvarci Eleanor H. Simpson Gaby Schneider Eric R. Kandel Jochen Roeper Torfi Sigurdsson
author_facet	Sevil Duvarci Eleanor H. Simpson Gaby Schneider Eric R. Kandel Jochen Roeper Torfi Sigurdsson
author_sort	Sevil Duvarci
title	Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression
title_short	Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression
title_full	Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression
title_fullStr	Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression
title_full_unstemmed	Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression
title_sort	impaired recruitment of dopamine neurons during working memory in mice with striatal d2 receptor overexpression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/80af5b334ef94206b731e0310e38cc3d
work_keys_str_mv	AT sevilduvarci impairedrecruitmentofdopamineneuronsduringworkingmemoryinmicewithstriatald2receptoroverexpression AT eleanorhsimpson impairedrecruitmentofdopamineneuronsduringworkingmemoryinmicewithstriatald2receptoroverexpression AT gabyschneider impairedrecruitmentofdopamineneuronsduringworkingmemoryinmicewithstriatald2receptoroverexpression AT ericrkandel impairedrecruitmentofdopamineneuronsduringworkingmemoryinmicewithstriatald2receptoroverexpression AT jochenroeper impairedrecruitmentofdopamineneuronsduringworkingmemoryinmicewithstriatald2receptoroverexpression AT torfisigurdsson impairedrecruitmentofdopamineneuronsduringworkingmemoryinmicewithstriatald2receptoroverexpression
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Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression

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