Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression
Disrupted dopamine neuron firing is thought to contribute to cognitive dysfunction in psychiatric disorders. Here the authors show that mice overexpressing D2R in the striatum, commonly seen in schizophrenia, are also impaired in recruitment of dopamine neurons during working memory performance.
Enregistré dans:
Auteurs principaux: | Sevil Duvarci, Eleanor H. Simpson, Gaby Schneider, Eric R. Kandel, Jochen Roeper, Torfi Sigurdsson |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/80af5b334ef94206b731e0310e38cc3d |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
par: Iku Tsutsui-Kimura, et autres
Publié: (2017) -
Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
par: Nicola J Platt, et autres
Publié: (2012) -
Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein
par: Raly James Perez Custodio, et autres
Publié: (2021) -
Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine.
par: Henrike Planert, et autres
Publié: (2013) -
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter
par: Mark D. Condon, et autres
Publié: (2019)