Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression

Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression

Disrupted dopamine neuron firing is thought to contribute to cognitive dysfunction in psychiatric disorders. Here the authors show that mice overexpressing D2R in the striatum, commonly seen in schizophrenia, are also impaired in recruitment of dopamine neurons during working memory performance.

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Autores principales: Sevil Duvarci, Eleanor H. Simpson, Gaby Schneider, Eric R. Kandel, Jochen Roeper, Torfi Sigurdsson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/80af5b334ef94206b731e0310e38cc3d
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