Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53

Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53

p53 is an oncosuppressor regulating several genes at the transcriptional level. Here, the authors identify a negative feedback loop between PHLDB3 and p53; PHLDB3 is a transcriptional target of p53 which facilitates MDM2-mediated p53 ubiquitination and degradation, impacting on tumorigenesis.

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Bibliographic Details
Main Authors: Tengfei Chao, Xiang Zhou, Bo Cao, Peng Liao, Hongbing Liu, Yun Chen, Hee-Won Park, Shelya X. Zeng, Hua Lu
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/80b0f7c208ef441c941d67f135a581cf
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Summary:p53 is an oncosuppressor regulating several genes at the transcriptional level. Here, the authors identify a negative feedback loop between PHLDB3 and p53; PHLDB3 is a transcriptional target of p53 which facilitates MDM2-mediated p53 ubiquitination and degradation, impacting on tumorigenesis.

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