Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53

Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53

p53 is an oncosuppressor regulating several genes at the transcriptional level. Here, the authors identify a negative feedback loop between PHLDB3 and p53; PHLDB3 is a transcriptional target of p53 which facilitates MDM2-mediated p53 ubiquitination and degradation, impacting on tumorigenesis.

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Autores principales: Tengfei Chao, Xiang Zhou, Bo Cao, Peng Liao, Hongbing Liu, Yun Chen, Hee-Won Park, Shelya X. Zeng, Hua Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/80b0f7c208ef441c941d67f135a581cf
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spelling oai:doaj.org-article:80b0f7c208ef441c941d67f135a581cf2021-12-02T14:39:29ZPleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p5310.1038/ncomms137552041-1723https://doaj.org/article/80b0f7c208ef441c941d67f135a581cf2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13755https://doaj.org/toc/2041-1723p53 is an oncosuppressor regulating several genes at the transcriptional level. Here, the authors identify a negative feedback loop between PHLDB3 and p53; PHLDB3 is a transcriptional target of p53 which facilitates MDM2-mediated p53 ubiquitination and degradation, impacting on tumorigenesis.Tengfei ChaoXiang ZhouBo CaoPeng LiaoHongbing LiuYun ChenHee-Won ParkShelya X. ZengHua LuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tengfei Chao
Xiang Zhou
Bo Cao
Peng Liao
Hongbing Liu
Yun Chen
Hee-Won Park
Shelya X. Zeng
Hua Lu
Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
description p53 is an oncosuppressor regulating several genes at the transcriptional level. Here, the authors identify a negative feedback loop between PHLDB3 and p53; PHLDB3 is a transcriptional target of p53 which facilitates MDM2-mediated p53 ubiquitination and degradation, impacting on tumorigenesis.
format article
author Tengfei Chao
Xiang Zhou
Bo Cao
Peng Liao
Hongbing Liu
Yun Chen
Hee-Won Park
Shelya X. Zeng
Hua Lu
author_facet Tengfei Chao
Xiang Zhou
Bo Cao
Peng Liao
Hongbing Liu
Yun Chen
Hee-Won Park
Shelya X. Zeng
Hua Lu
author_sort Tengfei Chao
title Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
title_short Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
title_full Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
title_fullStr Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
title_full_unstemmed Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
title_sort pleckstrin homology domain-containing protein phldb3 supports cancer growth via a negative feedback loop involving p53
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/80b0f7c208ef441c941d67f135a581cf
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