A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing

Decreased autophagy is a hallmark of ageing, but its inter-tissue regulation is poorly understood. Here, Zhou et al. identify mir-83 in C. elegans, which is transported across tissues and suppresses autophagy, contributing to age-related decline.

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Autores principales:	Yifei Zhou, Xueqing Wang, Mengjiao Song, Zhidong He, Guizhong Cui, Guangdun Peng, Christoph Dieterich, Adam Antebi, Naihe Jing, Yidong Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80b2ae124c734704ad45ea80c8f0c35c
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spelling	oai:doaj.org-article:80b2ae124c734704ad45ea80c8f0c35c2021-12-02T17:02:08ZA secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing10.1038/s41467-019-12821-22041-1723https://doaj.org/article/80b2ae124c734704ad45ea80c8f0c35c2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12821-2https://doaj.org/toc/2041-1723Decreased autophagy is a hallmark of ageing, but its inter-tissue regulation is poorly understood. Here, Zhou et al. identify mir-83 in C. elegans, which is transported across tissues and suppresses autophagy, contributing to age-related decline.Yifei ZhouXueqing WangMengjiao SongZhidong HeGuizhong CuiGuangdun PengChristoph DieterichAdam AntebiNaihe JingYidong ShenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yifei Zhou Xueqing Wang Mengjiao Song Zhidong He Guizhong Cui Guangdun Peng Christoph Dieterich Adam Antebi Naihe Jing Yidong Shen A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing
description	Decreased autophagy is a hallmark of ageing, but its inter-tissue regulation is poorly understood. Here, Zhou et al. identify mir-83 in C. elegans, which is transported across tissues and suppresses autophagy, contributing to age-related decline.
format	article
author	Yifei Zhou Xueqing Wang Mengjiao Song Zhidong He Guizhong Cui Guangdun Peng Christoph Dieterich Adam Antebi Naihe Jing Yidong Shen
author_facet	Yifei Zhou Xueqing Wang Mengjiao Song Zhidong He Guizhong Cui Guangdun Peng Christoph Dieterich Adam Antebi Naihe Jing Yidong Shen
author_sort	Yifei Zhou
title	A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing
title_short	A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing
title_full	A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing
title_fullStr	A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing
title_full_unstemmed	A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing
title_sort	secreted microrna disrupts autophagy in distinct tissues of caenorhabditis elegans upon ageing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/80b2ae124c734704ad45ea80c8f0c35c
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A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing

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