Anti-HIV-1 Activity of Lactic Acid in Human Cervicovaginal Fluid

ABSTRACT Women of reproductive age with a Lactobacillus-dominated vaginal microbiota have a reduced risk of acquiring and transmitting HIV and a vaginal pH of ~4 due to the presence of ~1% (wt/vol) lactic acid. While lactic acid has potent HIV virucidal activity in vitro, whether lactic acid present...

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Bibliographic Details
Main Authors: David Tyssen, Ying-Ying Wang, Joshua A. Hayward, Paul A. Agius, Kevin DeLong, Muriel Aldunate, Jacques Ravel, Thomas R. Moench, Richard A. Cone, Gilda Tachedjian
Format: article
Language:EN
Published: American Society for Microbiology 2018
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Online Access:https://doaj.org/article/80b414df21a043c5a01f64c330c1b08f
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