Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons

Although cortical GABAergic interneuron (CIN) dysfunction is implicated in several neuropsychiatric disorders, we still know very little about how they attain their unique properties or how their dysfunction impacts neuropsychiatric disorders. In this study, authors show that conditional loss of Tsc...

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Autores principales:	Ruchi Malik, Emily Ling-Lin Pai, Anna N Rubin, April M Stafford, Kartik Angara, Petros Minasi, John L. Rubenstein, Vikaas S Sohal, Daniel Vogt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80b4682b9d2d4e25bfb4a1bda0b1e7cc
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spelling	oai:doaj.org-article:80b4682b9d2d4e25bfb4a1bda0b1e7cc2021-12-02T16:51:00ZTsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons10.1038/s41467-019-12962-42041-1723https://doaj.org/article/80b4682b9d2d4e25bfb4a1bda0b1e7cc2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12962-4https://doaj.org/toc/2041-1723Although cortical GABAergic interneuron (CIN) dysfunction is implicated in several neuropsychiatric disorders, we still know very little about how they attain their unique properties or how their dysfunction impacts neuropsychiatric disorders. In this study, authors show that conditional loss of Tsc1, causes SST+ CINs, which are distinct from PV+ CINs, to express PV and adopt fast-spiking properties, via MTOR activityRuchi MalikEmily Ling-Lin PaiAnna N RubinApril M StaffordKartik AngaraPetros MinasiJohn L. RubensteinVikaas S SohalDaniel VogtNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruchi Malik Emily Ling-Lin Pai Anna N Rubin April M Stafford Kartik Angara Petros Minasi John L. Rubenstein Vikaas S Sohal Daniel Vogt Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons
description	Although cortical GABAergic interneuron (CIN) dysfunction is implicated in several neuropsychiatric disorders, we still know very little about how they attain their unique properties or how their dysfunction impacts neuropsychiatric disorders. In this study, authors show that conditional loss of Tsc1, causes SST+ CINs, which are distinct from PV+ CINs, to express PV and adopt fast-spiking properties, via MTOR activity
format	article
author	Ruchi Malik Emily Ling-Lin Pai Anna N Rubin April M Stafford Kartik Angara Petros Minasi John L. Rubenstein Vikaas S Sohal Daniel Vogt
author_facet	Ruchi Malik Emily Ling-Lin Pai Anna N Rubin April M Stafford Kartik Angara Petros Minasi John L. Rubenstein Vikaas S Sohal Daniel Vogt
author_sort	Ruchi Malik
title	Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons
title_short	Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons
title_full	Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons
title_fullStr	Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons
title_full_unstemmed	Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons
title_sort	tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/80b4682b9d2d4e25bfb4a1bda0b1e7cc
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Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons

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