A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination

Homology directed repair of meiotic double-strand breaks functions via recruitment and assembly of strand-exchange proteins called recombinases. Here the authors reveal and characterize a BRCA2 interactor regulating meiotic recombinases that localizes to chromosomal axes and facilitates the repair o...

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Autores principales:	Jingjing Zhang, Yasuhiro Fujiwara, Shohei Yamamoto, Hiroki Shibuya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80b66e3ab2cc434d8cba8b6989ae4516
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spelling	oai:doaj.org-article:80b66e3ab2cc434d8cba8b6989ae45162021-12-02T15:35:09ZA meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination10.1038/s41467-019-08676-22041-1723https://doaj.org/article/80b66e3ab2cc434d8cba8b6989ae45162019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08676-2https://doaj.org/toc/2041-1723Homology directed repair of meiotic double-strand breaks functions via recruitment and assembly of strand-exchange proteins called recombinases. Here the authors reveal and characterize a BRCA2 interactor regulating meiotic recombinases that localizes to chromosomal axes and facilitates the repair of meiotic DSBs.Jingjing ZhangYasuhiro FujiwaraShohei YamamotoHiroki ShibuyaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingjing Zhang Yasuhiro Fujiwara Shohei Yamamoto Hiroki Shibuya A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination
description	Homology directed repair of meiotic double-strand breaks functions via recruitment and assembly of strand-exchange proteins called recombinases. Here the authors reveal and characterize a BRCA2 interactor regulating meiotic recombinases that localizes to chromosomal axes and facilitates the repair of meiotic DSBs.
format	article
author	Jingjing Zhang Yasuhiro Fujiwara Shohei Yamamoto Hiroki Shibuya
author_facet	Jingjing Zhang Yasuhiro Fujiwara Shohei Yamamoto Hiroki Shibuya
author_sort	Jingjing Zhang
title	A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination
title_short	A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination
title_full	A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination
title_fullStr	A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination
title_full_unstemmed	A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination
title_sort	meiosis-specific brca2 binding protein recruits recombinases to dna double-strand breaks to ensure homologous recombination
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/80b66e3ab2cc434d8cba8b6989ae4516
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A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination

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