Continuous Flow Synthesis of Anticancer Drugs

Continuous flow chemistry is by now an established and valued synthesis technology regularly exploited in academic and industrial laboratories to bring about the improved preparation of a variety of molecular structures. Benefits such as better heat and mass transfer, improved process control and sa...

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Auteurs principaux:	Mara Di Filippo, Marcus Baumann
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	flow synthesis API anticancer drug process control reaction telescoping drug synthesis Organic chemistry QD241-441
Accès en ligne:	https://doaj.org/article/80b914f8a1b0406dbb46cb515e4995c6
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spelling	oai:doaj.org-article:80b914f8a1b0406dbb46cb515e4995c62021-11-25T18:28:58ZContinuous Flow Synthesis of Anticancer Drugs10.3390/molecules262269921420-3049https://doaj.org/article/80b914f8a1b0406dbb46cb515e4995c62021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6992https://doaj.org/toc/1420-3049Continuous flow chemistry is by now an established and valued synthesis technology regularly exploited in academic and industrial laboratories to bring about the improved preparation of a variety of molecular structures. Benefits such as better heat and mass transfer, improved process control and safety, a small equipment footprint, as well as the ability to integrate in-line analysis and purification tools into telescoped sequences are often cited when comparing flow to analogous batch processes. In this short review, the latest developments regarding the exploitation of continuous flow protocols towards the synthesis of anticancer drugs are evaluated. Our efforts focus predominately on the period of 2016–2021 and highlight key case studies where either the final active pharmaceutical ingredient (API) or its building blocks were produced continuously. It is hoped that this manuscript will serve as a useful synopsis showcasing the impact of continuous flow chemistry towards the generation of important anticancer drugs.Mara Di FilippoMarcus BaumannMDPI AGarticleflow synthesisAPIanticancer drugprocess controlreaction telescopingdrug synthesisOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6992, p 6992 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flow synthesis API anticancer drug process control reaction telescoping drug synthesis Organic chemistry QD241-441
spellingShingle	flow synthesis API anticancer drug process control reaction telescoping drug synthesis Organic chemistry QD241-441 Mara Di Filippo Marcus Baumann Continuous Flow Synthesis of Anticancer Drugs
description	Continuous flow chemistry is by now an established and valued synthesis technology regularly exploited in academic and industrial laboratories to bring about the improved preparation of a variety of molecular structures. Benefits such as better heat and mass transfer, improved process control and safety, a small equipment footprint, as well as the ability to integrate in-line analysis and purification tools into telescoped sequences are often cited when comparing flow to analogous batch processes. In this short review, the latest developments regarding the exploitation of continuous flow protocols towards the synthesis of anticancer drugs are evaluated. Our efforts focus predominately on the period of 2016–2021 and highlight key case studies where either the final active pharmaceutical ingredient (API) or its building blocks were produced continuously. It is hoped that this manuscript will serve as a useful synopsis showcasing the impact of continuous flow chemistry towards the generation of important anticancer drugs.
format	article
author	Mara Di Filippo Marcus Baumann
author_facet	Mara Di Filippo Marcus Baumann
author_sort	Mara Di Filippo
title	Continuous Flow Synthesis of Anticancer Drugs
title_short	Continuous Flow Synthesis of Anticancer Drugs
title_full	Continuous Flow Synthesis of Anticancer Drugs
title_fullStr	Continuous Flow Synthesis of Anticancer Drugs
title_full_unstemmed	Continuous Flow Synthesis of Anticancer Drugs
title_sort	continuous flow synthesis of anticancer drugs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/80b914f8a1b0406dbb46cb515e4995c6
work_keys_str_mv	AT maradifilippo continuousflowsynthesisofanticancerdrugs AT marcusbaumann continuousflowsynthesisofanticancerdrugs
_version_	1718411085646659584

Continuous Flow Synthesis of Anticancer Drugs

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