Sarcopenia is independently associated with diabetic foot disease

Abstract The aim of this study was to investigate the association of sarcopenia and diabetic foot disease (DFD) in a cross-sectional study. Body composition was assessed using dual-energy X-ray-absorptiometry (DXA) among 1105 patients with type 2 diabetes (120 patients with newly diagnosed DFD [DFD...

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Autores principales:	Qingfeng Cheng, Jinbo Hu, Ping Yang, Xueting Cao, Xuefeng Deng, Qin Yang, Zhiping Liu, Shumin Yang, Richa Goswami, Yue Wang, Ting Luo, Kun Liao, Qifu Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/80bae18d7cb4409faaf58bb2e4192e7f
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spelling	oai:doaj.org-article:80bae18d7cb4409faaf58bb2e4192e7f2021-12-02T16:06:34ZSarcopenia is independently associated with diabetic foot disease10.1038/s41598-017-08972-12045-2322https://doaj.org/article/80bae18d7cb4409faaf58bb2e4192e7f2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08972-1https://doaj.org/toc/2045-2322Abstract The aim of this study was to investigate the association of sarcopenia and diabetic foot disease (DFD) in a cross-sectional study. Body composition was assessed using dual-energy X-ray-absorptiometry (DXA) among 1105 patients with type 2 diabetes (120 patients with newly diagnosed DFD [DFD duration less than 3 months]). Severity of DFD was assessed, referring to foot ulcers, Wagner grade and the percentage of amputation. Skeletal muscle index (SMI) was calculated, and sarcopenia was defined as SMI less than 7.0 kg/m2 (in men) or 5.4 kg/m2 (in women). SMI was significantly decreased in patients with DFD compared to patients without (6.79 ± 1.20 vs. 7.21 ± 1.05 kg/m2, P < 0.001). The percentage of sarcopenia in DFD patients was more than double than those without DFD (35.3% vs. 16.4%, P < 0.001). Multivariable logistic regression analysis showed that sarcopenia was independently associated with DFD (OR 2.05[95% CI 1.15,3.89], P = 0.027) after controlling confounders including age, diabetic duration and diabetic chronic complications. In DFD group, patients with sarcopenia exhibited more foot ulcers, higher Wagner grade and greater percentage of amputation compared to patients without sarcopenia. We conclude that sarcopenia is independently associated with DFD. Worse prognosis is seen in patients with DFD accompanied by sarcopenia.Qingfeng ChengJinbo HuPing YangXueting CaoXuefeng DengQin YangZhiping LiuShumin YangRicha GoswamiYue WangTing LuoKun LiaoQifu LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qingfeng Cheng Jinbo Hu Ping Yang Xueting Cao Xuefeng Deng Qin Yang Zhiping Liu Shumin Yang Richa Goswami Yue Wang Ting Luo Kun Liao Qifu Li Sarcopenia is independently associated with diabetic foot disease
description	Abstract The aim of this study was to investigate the association of sarcopenia and diabetic foot disease (DFD) in a cross-sectional study. Body composition was assessed using dual-energy X-ray-absorptiometry (DXA) among 1105 patients with type 2 diabetes (120 patients with newly diagnosed DFD [DFD duration less than 3 months]). Severity of DFD was assessed, referring to foot ulcers, Wagner grade and the percentage of amputation. Skeletal muscle index (SMI) was calculated, and sarcopenia was defined as SMI less than 7.0 kg/m2 (in men) or 5.4 kg/m2 (in women). SMI was significantly decreased in patients with DFD compared to patients without (6.79 ± 1.20 vs. 7.21 ± 1.05 kg/m2, P < 0.001). The percentage of sarcopenia in DFD patients was more than double than those without DFD (35.3% vs. 16.4%, P < 0.001). Multivariable logistic regression analysis showed that sarcopenia was independently associated with DFD (OR 2.05[95% CI 1.15,3.89], P = 0.027) after controlling confounders including age, diabetic duration and diabetic chronic complications. In DFD group, patients with sarcopenia exhibited more foot ulcers, higher Wagner grade and greater percentage of amputation compared to patients without sarcopenia. We conclude that sarcopenia is independently associated with DFD. Worse prognosis is seen in patients with DFD accompanied by sarcopenia.
format	article
author	Qingfeng Cheng Jinbo Hu Ping Yang Xueting Cao Xuefeng Deng Qin Yang Zhiping Liu Shumin Yang Richa Goswami Yue Wang Ting Luo Kun Liao Qifu Li
author_facet	Qingfeng Cheng Jinbo Hu Ping Yang Xueting Cao Xuefeng Deng Qin Yang Zhiping Liu Shumin Yang Richa Goswami Yue Wang Ting Luo Kun Liao Qifu Li
author_sort	Qingfeng Cheng
title	Sarcopenia is independently associated with diabetic foot disease
title_short	Sarcopenia is independently associated with diabetic foot disease
title_full	Sarcopenia is independently associated with diabetic foot disease
title_fullStr	Sarcopenia is independently associated with diabetic foot disease
title_full_unstemmed	Sarcopenia is independently associated with diabetic foot disease
title_sort	sarcopenia is independently associated with diabetic foot disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/80bae18d7cb4409faaf58bb2e4192e7f
work_keys_str_mv	AT qingfengcheng sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT jinbohu sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT pingyang sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT xuetingcao sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT xuefengdeng sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT qinyang sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT zhipingliu sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT shuminyang sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT richagoswami sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT yuewang sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT tingluo sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT kunliao sarcopeniaisindependentlyassociatedwithdiabeticfootdisease AT qifuli sarcopeniaisindependentlyassociatedwithdiabeticfootdisease
_version_	1718384972303171584

Sarcopenia is independently associated with diabetic foot disease

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