Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint

Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses from human liver and hepatocellular carcinoma.

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Autores principales:	Nathalie M. Schmidt, Peter A. C. Wing, Mariana O. Diniz, Laura J. Pallett, Leo Swadling, James M. Harris, Alice R. Burton, Anna Jeffery-Smith, Nekisa Zakeri, Oliver E. Amin, Stephanie Kucykowicz, Mirjam H. Heemskerk, Brian Davidson, Tim Meyer, Joe Grove, Hans J. Stauss, Ines Pineda-Torra, Clare Jolly, Elizabeth C. Jury, Jane A. McKeating, Mala K. Maini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80c091a62a0e452aadda8e67b452162c
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spelling	oai:doaj.org-article:80c091a62a0e452aadda8e67b452162c2021-12-02T15:54:58ZTargeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint10.1038/s41467-021-22967-72041-1723https://doaj.org/article/80c091a62a0e452aadda8e67b452162c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22967-7https://doaj.org/toc/2041-1723Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses from human liver and hepatocellular carcinoma.Nathalie M. SchmidtPeter A. C. WingMariana O. DinizLaura J. PallettLeo SwadlingJames M. HarrisAlice R. BurtonAnna Jeffery-SmithNekisa ZakeriOliver E. AminStephanie KucykowiczMirjam H. HeemskerkBrian DavidsonTim MeyerJoe GroveHans J. StaussInes Pineda-TorraClare JollyElizabeth C. JuryJane A. McKeatingMala K. MainiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathalie M. Schmidt Peter A. C. Wing Mariana O. Diniz Laura J. Pallett Leo Swadling James M. Harris Alice R. Burton Anna Jeffery-Smith Nekisa Zakeri Oliver E. Amin Stephanie Kucykowicz Mirjam H. Heemskerk Brian Davidson Tim Meyer Joe Grove Hans J. Stauss Ines Pineda-Torra Clare Jolly Elizabeth C. Jury Jane A. McKeating Mala K. Maini Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
description	Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses from human liver and hepatocellular carcinoma.
format	article
author	Nathalie M. Schmidt Peter A. C. Wing Mariana O. Diniz Laura J. Pallett Leo Swadling James M. Harris Alice R. Burton Anna Jeffery-Smith Nekisa Zakeri Oliver E. Amin Stephanie Kucykowicz Mirjam H. Heemskerk Brian Davidson Tim Meyer Joe Grove Hans J. Stauss Ines Pineda-Torra Clare Jolly Elizabeth C. Jury Jane A. McKeating Mala K. Maini
author_facet	Nathalie M. Schmidt Peter A. C. Wing Mariana O. Diniz Laura J. Pallett Leo Swadling James M. Harris Alice R. Burton Anna Jeffery-Smith Nekisa Zakeri Oliver E. Amin Stephanie Kucykowicz Mirjam H. Heemskerk Brian Davidson Tim Meyer Joe Grove Hans J. Stauss Ines Pineda-Torra Clare Jolly Elizabeth C. Jury Jane A. McKeating Mala K. Maini
author_sort	Nathalie M. Schmidt
title	Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
title_short	Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
title_full	Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
title_fullStr	Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
title_full_unstemmed	Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
title_sort	targeting human acyl-coa:cholesterol acyltransferase as a dual viral and t cell metabolic checkpoint
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/80c091a62a0e452aadda8e67b452162c
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Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint

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