Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade

Tumor associated neutrophils have been correlated with poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Here the authors show that the tyrosine kinase inhibitor lorlatinib modulates neutrophil development and recruitment in the tumor microenvironment, attenuating PDAC progres...

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Autores principales:	Sebastian R. Nielsen, Jan E. Strøbech, Edward R. Horton, Rene Jackstadt, Anu Laitala, Marina C. Bravo, Giorgia Maltese, Adina R. D. Jensen, Raphael Reuten, Maria Rafaeva, Saadia A. Karim, Chang-Il Hwang, Luis Arnes, David A. Tuveson, Owen J. Sansom, Jennifer P. Morton, Janine T. Erler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80c3347050694832b4503df3a10d5b8d
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spelling	oai:doaj.org-article:80c3347050694832b4503df3a10d5b8d2021-12-02T17:47:14ZSuppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade10.1038/s41467-021-23731-72041-1723https://doaj.org/article/80c3347050694832b4503df3a10d5b8d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23731-7https://doaj.org/toc/2041-1723Tumor associated neutrophils have been correlated with poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Here the authors show that the tyrosine kinase inhibitor lorlatinib modulates neutrophil development and recruitment in the tumor microenvironment, attenuating PDAC progression in preclinical mouse models.Sebastian R. NielsenJan E. StrøbechEdward R. HortonRene JackstadtAnu LaitalaMarina C. BravoGiorgia MalteseAdina R. D. JensenRaphael ReutenMaria RafaevaSaadia A. KarimChang-Il HwangLuis ArnesDavid A. TuvesonOwen J. SansomJennifer P. MortonJanine T. ErlerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastian R. Nielsen Jan E. Strøbech Edward R. Horton Rene Jackstadt Anu Laitala Marina C. Bravo Giorgia Maltese Adina R. D. Jensen Raphael Reuten Maria Rafaeva Saadia A. Karim Chang-Il Hwang Luis Arnes David A. Tuveson Owen J. Sansom Jennifer P. Morton Janine T. Erler Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade
description	Tumor associated neutrophils have been correlated with poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Here the authors show that the tyrosine kinase inhibitor lorlatinib modulates neutrophil development and recruitment in the tumor microenvironment, attenuating PDAC progression in preclinical mouse models.
format	article
author	Sebastian R. Nielsen Jan E. Strøbech Edward R. Horton Rene Jackstadt Anu Laitala Marina C. Bravo Giorgia Maltese Adina R. D. Jensen Raphael Reuten Maria Rafaeva Saadia A. Karim Chang-Il Hwang Luis Arnes David A. Tuveson Owen J. Sansom Jennifer P. Morton Janine T. Erler
author_facet	Sebastian R. Nielsen Jan E. Strøbech Edward R. Horton Rene Jackstadt Anu Laitala Marina C. Bravo Giorgia Maltese Adina R. D. Jensen Raphael Reuten Maria Rafaeva Saadia A. Karim Chang-Il Hwang Luis Arnes David A. Tuveson Owen J. Sansom Jennifer P. Morton Janine T. Erler
author_sort	Sebastian R. Nielsen
title	Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade
title_short	Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade
title_full	Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade
title_fullStr	Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade
title_full_unstemmed	Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade
title_sort	suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/80c3347050694832b4503df3a10d5b8d
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Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade

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