Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas
Diabetes results in part from a deficiency of functional pancreatic beta cells. Here, the authors study the genomic and epigenetic landscapes of human insulinomas to gain insight into possible pathways for therapeutic beta cell regeneration, highlighting epigenetic genes and pathways.
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Nature Portfolio
2017
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oai:doaj.org-article:80c3e45c47014686a61554de1f26c1c12021-12-02T14:40:48ZInsights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas10.1038/s41467-017-00992-92041-1723https://doaj.org/article/80c3e45c47014686a61554de1f26c1c12017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00992-9https://doaj.org/toc/2041-1723Diabetes results in part from a deficiency of functional pancreatic beta cells. Here, the authors study the genomic and epigenetic landscapes of human insulinomas to gain insight into possible pathways for therapeutic beta cell regeneration, highlighting epigenetic genes and pathways.Huan WangAaron BenderPeng WangEsra KarakoseWilliam B. InabnetSteven K. LibuttiAndrew ArnoldLuca LambertiniMicheal StangHerbert ChenYumi KasaiMilind MahajanYayoi KinoshitaGustavo Fernandez-RanvierThomas C. BeckerKaren K. TakaneLaura A. WalkerShira SaulRong ChenDonald K. ScottJorge FerrerYevgeniy AntipinMichael DonovanAndrew V. UzilovBoris RevaEric E. SchadtBojan LosicCarmen ArgmannAndrew F. StewartNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Huan Wang Aaron Bender Peng Wang Esra Karakose William B. Inabnet Steven K. Libutti Andrew Arnold Luca Lambertini Micheal Stang Herbert Chen Yumi Kasai Milind Mahajan Yayoi Kinoshita Gustavo Fernandez-Ranvier Thomas C. Becker Karen K. Takane Laura A. Walker Shira Saul Rong Chen Donald K. Scott Jorge Ferrer Yevgeniy Antipin Michael Donovan Andrew V. Uzilov Boris Reva Eric E. Schadt Bojan Losic Carmen Argmann Andrew F. Stewart Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas |
| description |
Diabetes results in part from a deficiency of functional pancreatic beta cells. Here, the authors study the genomic and epigenetic landscapes of human insulinomas to gain insight into possible pathways for therapeutic beta cell regeneration, highlighting epigenetic genes and pathways. |
| format |
article |
| author |
Huan Wang Aaron Bender Peng Wang Esra Karakose William B. Inabnet Steven K. Libutti Andrew Arnold Luca Lambertini Micheal Stang Herbert Chen Yumi Kasai Milind Mahajan Yayoi Kinoshita Gustavo Fernandez-Ranvier Thomas C. Becker Karen K. Takane Laura A. Walker Shira Saul Rong Chen Donald K. Scott Jorge Ferrer Yevgeniy Antipin Michael Donovan Andrew V. Uzilov Boris Reva Eric E. Schadt Bojan Losic Carmen Argmann Andrew F. Stewart |
| author_facet |
Huan Wang Aaron Bender Peng Wang Esra Karakose William B. Inabnet Steven K. Libutti Andrew Arnold Luca Lambertini Micheal Stang Herbert Chen Yumi Kasai Milind Mahajan Yayoi Kinoshita Gustavo Fernandez-Ranvier Thomas C. Becker Karen K. Takane Laura A. Walker Shira Saul Rong Chen Donald K. Scott Jorge Ferrer Yevgeniy Antipin Michael Donovan Andrew V. Uzilov Boris Reva Eric E. Schadt Bojan Losic Carmen Argmann Andrew F. Stewart |
| author_sort |
Huan Wang |
| title |
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas |
| title_short |
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas |
| title_full |
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas |
| title_fullStr |
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas |
| title_full_unstemmed |
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas |
| title_sort |
insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/80c3e45c47014686a61554de1f26c1c1 |
| work_keys_str_mv |
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