Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer

In prostate cancer tumour aggressiveness can be related to race. Here, the authors identify an alternative RNA splice variant of PIK3CD as a potential mechanism to explain racial disparities in the incidence and aggressiveness of prostate cancer between African American and European American men.

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Autores principales:	Bi-Dar Wang, Kristin Ceniccola, SuJin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A. Freedman, Jacqueline Olender, Stefan Knapp, Travers Ching, Lana Garmire, Vyomesh Patel, Mariano A. Garcia-Blanco, Steven R. Patierno, Norman H. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80c476f7db414f898da67a1d441f9eec
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spelling	oai:doaj.org-article:80c476f7db414f898da67a1d441f9eec2021-12-02T15:38:41ZAlternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer10.1038/ncomms159212041-1723https://doaj.org/article/80c476f7db414f898da67a1d441f9eec2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15921https://doaj.org/toc/2041-1723In prostate cancer tumour aggressiveness can be related to race. Here, the authors identify an alternative RNA splice variant of PIK3CD as a potential mechanism to explain racial disparities in the incidence and aggressiveness of prostate cancer between African American and European American men.Bi-Dar WangKristin CeniccolaSuJin HwangRamez AndrawisAnelia HorvathJennifer A. FreedmanJacqueline OlenderStefan KnappTravers ChingLana GarmireVyomesh PatelMariano A. Garcia-BlancoSteven R. PatiernoNorman H. LeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bi-Dar Wang Kristin Ceniccola SuJin Hwang Ramez Andrawis Anelia Horvath Jennifer A. Freedman Jacqueline Olender Stefan Knapp Travers Ching Lana Garmire Vyomesh Patel Mariano A. Garcia-Blanco Steven R. Patierno Norman H. Lee Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer
description	In prostate cancer tumour aggressiveness can be related to race. Here, the authors identify an alternative RNA splice variant of PIK3CD as a potential mechanism to explain racial disparities in the incidence and aggressiveness of prostate cancer between African American and European American men.
format	article
author	Bi-Dar Wang Kristin Ceniccola SuJin Hwang Ramez Andrawis Anelia Horvath Jennifer A. Freedman Jacqueline Olender Stefan Knapp Travers Ching Lana Garmire Vyomesh Patel Mariano A. Garcia-Blanco Steven R. Patierno Norman H. Lee
author_facet	Bi-Dar Wang Kristin Ceniccola SuJin Hwang Ramez Andrawis Anelia Horvath Jennifer A. Freedman Jacqueline Olender Stefan Knapp Travers Ching Lana Garmire Vyomesh Patel Mariano A. Garcia-Blanco Steven R. Patierno Norman H. Lee
author_sort	Bi-Dar Wang
title	Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer
title_short	Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer
title_full	Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer
title_fullStr	Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer
title_full_unstemmed	Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer
title_sort	alternative splicing promotes tumour aggressiveness and drug resistance in african american prostate cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/80c476f7db414f898da67a1d441f9eec
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Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer

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