Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells
Zika virus (ZIKV) can infect the central nervous system, but it is not clear how it reaches the brain. Here, Ayala-Nunez et al. show in ex vivo and in vivo models that ZIKV can hitch a ride in monocytes in a Trojan Horse manner to cross the endothelium and disseminate the virus.
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Nature Portfolio
2019
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oai:doaj.org-article:80c8125c989f4ad684da8d5bd85923172021-12-02T17:02:01ZZika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells10.1038/s41467-019-12408-x2041-1723https://doaj.org/article/80c8125c989f4ad684da8d5bd85923172019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12408-xhttps://doaj.org/toc/2041-1723Zika virus (ZIKV) can infect the central nervous system, but it is not clear how it reaches the brain. Here, Ayala-Nunez et al. show in ex vivo and in vivo models that ZIKV can hitch a ride in monocytes in a Trojan Horse manner to cross the endothelium and disseminate the virus.Nilda Vanesa Ayala-NunezGautier FollainFrançois DelalandeAurélie HirschlerEmma PartiotGillian L. HaleBrigid C. BollwegJudith RoelsMaxime ChazalFlorian BakoaMargot CarocciSandrine BourdoulousOrestis FaklarisSherif R. ZakiAnita EcklyBéatrice Uring-LambertFrédéric DoussauSarah CianferaniChristine CarapitoFrank M. J. JacobsNolwenn JouvenetJacky G. GoetzRaphael GaudinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Nilda Vanesa Ayala-Nunez Gautier Follain François Delalande Aurélie Hirschler Emma Partiot Gillian L. Hale Brigid C. Bollweg Judith Roels Maxime Chazal Florian Bakoa Margot Carocci Sandrine Bourdoulous Orestis Faklaris Sherif R. Zaki Anita Eckly Béatrice Uring-Lambert Frédéric Doussau Sarah Cianferani Christine Carapito Frank M. J. Jacobs Nolwenn Jouvenet Jacky G. Goetz Raphael Gaudin Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells |
| description |
Zika virus (ZIKV) can infect the central nervous system, but it is not clear how it reaches the brain. Here, Ayala-Nunez et al. show in ex vivo and in vivo models that ZIKV can hitch a ride in monocytes in a Trojan Horse manner to cross the endothelium and disseminate the virus. |
| format |
article |
| author |
Nilda Vanesa Ayala-Nunez Gautier Follain François Delalande Aurélie Hirschler Emma Partiot Gillian L. Hale Brigid C. Bollweg Judith Roels Maxime Chazal Florian Bakoa Margot Carocci Sandrine Bourdoulous Orestis Faklaris Sherif R. Zaki Anita Eckly Béatrice Uring-Lambert Frédéric Doussau Sarah Cianferani Christine Carapito Frank M. J. Jacobs Nolwenn Jouvenet Jacky G. Goetz Raphael Gaudin |
| author_facet |
Nilda Vanesa Ayala-Nunez Gautier Follain François Delalande Aurélie Hirschler Emma Partiot Gillian L. Hale Brigid C. Bollweg Judith Roels Maxime Chazal Florian Bakoa Margot Carocci Sandrine Bourdoulous Orestis Faklaris Sherif R. Zaki Anita Eckly Béatrice Uring-Lambert Frédéric Doussau Sarah Cianferani Christine Carapito Frank M. J. Jacobs Nolwenn Jouvenet Jacky G. Goetz Raphael Gaudin |
| author_sort |
Nilda Vanesa Ayala-Nunez |
| title |
Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells |
| title_short |
Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells |
| title_full |
Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells |
| title_fullStr |
Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells |
| title_full_unstemmed |
Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells |
| title_sort |
zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/80c8125c989f4ad684da8d5bd8592317 |
| work_keys_str_mv |
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