In Vivo Biodistribution, Clearance, and Biocompatibility of Multiple Carbon Dots Containing Nanoparticles for Biomedical Application

Current research on the use of carbon dots for various biological systems mainly focuses on the single carbon dots, while particles that contain multiple carbon dots have scarcely been investigated. Here, we assessed multiple carbon dots-crosslinked polyethyleneimine nanoparticles (CDs@PEI) for thei...

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Autores principales:	Jinfeng Liao, Yuan Yao, Cheng-Hao Lee, Yongzhi Wu, Pei Li
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multiple carbon-dot nanoparticle single carbon dot biodistribution clearance biocompatibility Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/80d1efdc14ea43a98b84303a583ccee6
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spelling	oai:doaj.org-article:80d1efdc14ea43a98b84303a583ccee62021-11-25T18:41:19ZIn Vivo Biodistribution, Clearance, and Biocompatibility of Multiple Carbon Dots Containing Nanoparticles for Biomedical Application10.3390/pharmaceutics131118721999-4923https://doaj.org/article/80d1efdc14ea43a98b84303a583ccee62021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1872https://doaj.org/toc/1999-4923Current research on the use of carbon dots for various biological systems mainly focuses on the single carbon dots, while particles that contain multiple carbon dots have scarcely been investigated. Here, we assessed multiple carbon dots-crosslinked polyethyleneimine nanoparticles (CDs@PEI) for their in vivo biodistribution, clearance, biocompatibility, and cellular uptake. The in vivo studies demonstrate three unique features of the CDs@PEI nanoparticles: (1) the nanoparticles possess tumor-targeting ability with steady and prolonged retention time in the tumor region. (2) The nanoparticles show hepatobiliary excretion and are clear from the intestine in feces. (3) The nanoparticles have much better biocompatibility than the polyethyleneimine passivated single carbon dots (PEI-CD). We also found that pegylated CDs@PEI nanoparticles can be effectively taken up by the cells, which the confocal laser scanning microscope can image under different excitation wavelengths (at 405, 488, and 800 nm). These prior studies provide invaluable information and new opportunities for this new type of intrinsic photoluminescence nanoparticles in carbon dot-based biomedical applications.Jinfeng LiaoYuan YaoCheng-Hao LeeYongzhi WuPei LiMDPI AGarticlemultiple carbon-dot nanoparticlesingle carbon dotbiodistributionclearancebiocompatibilityPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1872, p 1872 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple carbon-dot nanoparticle single carbon dot biodistribution clearance biocompatibility Pharmacy and materia medica RS1-441
spellingShingle	multiple carbon-dot nanoparticle single carbon dot biodistribution clearance biocompatibility Pharmacy and materia medica RS1-441 Jinfeng Liao Yuan Yao Cheng-Hao Lee Yongzhi Wu Pei Li In Vivo Biodistribution, Clearance, and Biocompatibility of Multiple Carbon Dots Containing Nanoparticles for Biomedical Application
description	Current research on the use of carbon dots for various biological systems mainly focuses on the single carbon dots, while particles that contain multiple carbon dots have scarcely been investigated. Here, we assessed multiple carbon dots-crosslinked polyethyleneimine nanoparticles (CDs@PEI) for their in vivo biodistribution, clearance, biocompatibility, and cellular uptake. The in vivo studies demonstrate three unique features of the CDs@PEI nanoparticles: (1) the nanoparticles possess tumor-targeting ability with steady and prolonged retention time in the tumor region. (2) The nanoparticles show hepatobiliary excretion and are clear from the intestine in feces. (3) The nanoparticles have much better biocompatibility than the polyethyleneimine passivated single carbon dots (PEI-CD). We also found that pegylated CDs@PEI nanoparticles can be effectively taken up by the cells, which the confocal laser scanning microscope can image under different excitation wavelengths (at 405, 488, and 800 nm). These prior studies provide invaluable information and new opportunities for this new type of intrinsic photoluminescence nanoparticles in carbon dot-based biomedical applications.
format	article
author	Jinfeng Liao Yuan Yao Cheng-Hao Lee Yongzhi Wu Pei Li
author_facet	Jinfeng Liao Yuan Yao Cheng-Hao Lee Yongzhi Wu Pei Li
author_sort	Jinfeng Liao
title	In Vivo Biodistribution, Clearance, and Biocompatibility of Multiple Carbon Dots Containing Nanoparticles for Biomedical Application
title_short	In Vivo Biodistribution, Clearance, and Biocompatibility of Multiple Carbon Dots Containing Nanoparticles for Biomedical Application
title_full	In Vivo Biodistribution, Clearance, and Biocompatibility of Multiple Carbon Dots Containing Nanoparticles for Biomedical Application
title_fullStr	In Vivo Biodistribution, Clearance, and Biocompatibility of Multiple Carbon Dots Containing Nanoparticles for Biomedical Application
title_full_unstemmed	In Vivo Biodistribution, Clearance, and Biocompatibility of Multiple Carbon Dots Containing Nanoparticles for Biomedical Application
title_sort	in vivo biodistribution, clearance, and biocompatibility of multiple carbon dots containing nanoparticles for biomedical application
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/80d1efdc14ea43a98b84303a583ccee6
work_keys_str_mv	AT jinfengliao invivobiodistributionclearanceandbiocompatibilityofmultiplecarbondotscontainingnanoparticlesforbiomedicalapplication AT yuanyao invivobiodistributionclearanceandbiocompatibilityofmultiplecarbondotscontainingnanoparticlesforbiomedicalapplication AT chenghaolee invivobiodistributionclearanceandbiocompatibilityofmultiplecarbondotscontainingnanoparticlesforbiomedicalapplication AT yongzhiwu invivobiodistributionclearanceandbiocompatibilityofmultiplecarbondotscontainingnanoparticlesforbiomedicalapplication AT peili invivobiodistributionclearanceandbiocompatibilityofmultiplecarbondotscontainingnanoparticlesforbiomedicalapplication
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In Vivo Biodistribution, Clearance, and Biocompatibility of Multiple Carbon Dots Containing Nanoparticles for Biomedical Application

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