The Protective Effect of Taurine on Oxidized Fish-Oil-Induced Liver Oxidative Stress and Intestinal Barrier-Function Impairment in Juvenile <i>Ictalurus punctatus</i>

Dietary lipids provide energy for growth and development and provide fatty acids necessary for normal structure and biological function. However, oxidized lipids cause oxidative stress and intestinal damage. An 8-week feeding trial with fresh fish oil (FFO, control group), oxidized fish oil (OFO), a...

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Autores principales:	Yong Shi, Yi Hu, Ziqin Wang, Jiancheng Zhou, Junzhi Zhang, Huan Zhong, Guihong Fu, Lei Zhong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	channel catfish oxidative damage immune response intestinal health signaling pathway Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/80d47c3dfe5f42be8e01a724863d22ca
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spelling	oai:doaj.org-article:80d47c3dfe5f42be8e01a724863d22ca2021-11-25T16:26:14ZThe Protective Effect of Taurine on Oxidized Fish-Oil-Induced Liver Oxidative Stress and Intestinal Barrier-Function Impairment in Juvenile <i>Ictalurus punctatus</i>10.3390/antiox101116902076-3921https://doaj.org/article/80d47c3dfe5f42be8e01a724863d22ca2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1690https://doaj.org/toc/2076-3921Dietary lipids provide energy for growth and development and provide fatty acids necessary for normal structure and biological function. However, oxidized lipids cause oxidative stress and intestinal damage. An 8-week feeding trial with fresh fish oil (FFO, control group), oxidized fish oil (OFO), and taurine-supplemented diets (OFOT, OFO + 0.2% of taurine) was conducted to evaluate the protective effect of taurine on oxidized fish-oil-induced liver oxidative stress and intestine impairment in juvenile <i>I</i><i>ctalurus</i><i>pun</i><i>cta</i><i>tus</i>. The results showed that (1) Growth performance was significantly lower in fish fed OFO than in those fed other diets, whereas the opposite occurred in the hepatosomatic index. (2) OFO-feeding significantly increased lipid deposition compared with the FFO group. The addition of taurine ameliorated the OFO-induced increase in lipid vacuolization in the liver, significantly upregulated <i>lpl</i> mRNA expression, and downregulated <i>fas</i> and <i>srebp1</i> mRNA expression. (3) OFO-feeding significantly reduced oxidative damage of liver. Compared with the OFO group, the OFOT group remarkably upregulated antioxidant enzyme mRNA expression through the Nrf2-Keap1 signaling pathway based on the transcriptional expression. (4) OFO diets induced intestinal physical and immune barrier damage. Compared with the OFO group, OFOT diets remarkably downregulated <i>il-1β</i>, <i>il-6</i>, <i>tnf-α</i>, and <i>il-8</i> mRNA expression and upregulated <i>tgf-β</i> mRNA expression through the NF-κB signaling pathway. Besides, the addition of taurine to OFO diets significantly upregulated <i>zo-2</i> and <i>zo-1</i> mRNA expression, and downregulated <i>claudin-15</i> and <i>claudin-12</i> mRNA expression. In conclusion, oxidized-fish-oil diets can cause negative physiological health effects in <i>I</i><i>ctalurus</i><i>pun</i><i>cta</i><i>tus</i>, while adding taurine can increase growth and antioxidant ability, reduce lipid deposition, and improve intestinal health.Yong ShiYi HuZiqin WangJiancheng ZhouJunzhi ZhangHuan ZhongGuihong FuLei ZhongMDPI AGarticlechannel catfishoxidative damageimmune responseintestinal healthsignaling pathwayTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1690, p 1690 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	channel catfish oxidative damage immune response intestinal health signaling pathway Therapeutics. Pharmacology RM1-950
spellingShingle	channel catfish oxidative damage immune response intestinal health signaling pathway Therapeutics. Pharmacology RM1-950 Yong Shi Yi Hu Ziqin Wang Jiancheng Zhou Junzhi Zhang Huan Zhong Guihong Fu Lei Zhong The Protective Effect of Taurine on Oxidized Fish-Oil-Induced Liver Oxidative Stress and Intestinal Barrier-Function Impairment in Juvenile <i>Ictalurus punctatus</i>
description	Dietary lipids provide energy for growth and development and provide fatty acids necessary for normal structure and biological function. However, oxidized lipids cause oxidative stress and intestinal damage. An 8-week feeding trial with fresh fish oil (FFO, control group), oxidized fish oil (OFO), and taurine-supplemented diets (OFOT, OFO + 0.2% of taurine) was conducted to evaluate the protective effect of taurine on oxidized fish-oil-induced liver oxidative stress and intestine impairment in juvenile <i>I</i><i>ctalurus</i><i>pun</i><i>cta</i><i>tus</i>. The results showed that (1) Growth performance was significantly lower in fish fed OFO than in those fed other diets, whereas the opposite occurred in the hepatosomatic index. (2) OFO-feeding significantly increased lipid deposition compared with the FFO group. The addition of taurine ameliorated the OFO-induced increase in lipid vacuolization in the liver, significantly upregulated <i>lpl</i> mRNA expression, and downregulated <i>fas</i> and <i>srebp1</i> mRNA expression. (3) OFO-feeding significantly reduced oxidative damage of liver. Compared with the OFO group, the OFOT group remarkably upregulated antioxidant enzyme mRNA expression through the Nrf2-Keap1 signaling pathway based on the transcriptional expression. (4) OFO diets induced intestinal physical and immune barrier damage. Compared with the OFO group, OFOT diets remarkably downregulated <i>il-1β</i>, <i>il-6</i>, <i>tnf-α</i>, and <i>il-8</i> mRNA expression and upregulated <i>tgf-β</i> mRNA expression through the NF-κB signaling pathway. Besides, the addition of taurine to OFO diets significantly upregulated <i>zo-2</i> and <i>zo-1</i> mRNA expression, and downregulated <i>claudin-15</i> and <i>claudin-12</i> mRNA expression. In conclusion, oxidized-fish-oil diets can cause negative physiological health effects in <i>I</i><i>ctalurus</i><i>pun</i><i>cta</i><i>tus</i>, while adding taurine can increase growth and antioxidant ability, reduce lipid deposition, and improve intestinal health.
format	article
author	Yong Shi Yi Hu Ziqin Wang Jiancheng Zhou Junzhi Zhang Huan Zhong Guihong Fu Lei Zhong
author_facet	Yong Shi Yi Hu Ziqin Wang Jiancheng Zhou Junzhi Zhang Huan Zhong Guihong Fu Lei Zhong
author_sort	Yong Shi
title	The Protective Effect of Taurine on Oxidized Fish-Oil-Induced Liver Oxidative Stress and Intestinal Barrier-Function Impairment in Juvenile <i>Ictalurus punctatus</i>
title_short	The Protective Effect of Taurine on Oxidized Fish-Oil-Induced Liver Oxidative Stress and Intestinal Barrier-Function Impairment in Juvenile <i>Ictalurus punctatus</i>
title_full	The Protective Effect of Taurine on Oxidized Fish-Oil-Induced Liver Oxidative Stress and Intestinal Barrier-Function Impairment in Juvenile <i>Ictalurus punctatus</i>
title_fullStr	The Protective Effect of Taurine on Oxidized Fish-Oil-Induced Liver Oxidative Stress and Intestinal Barrier-Function Impairment in Juvenile <i>Ictalurus punctatus</i>
title_full_unstemmed	The Protective Effect of Taurine on Oxidized Fish-Oil-Induced Liver Oxidative Stress and Intestinal Barrier-Function Impairment in Juvenile <i>Ictalurus punctatus</i>
title_sort	protective effect of taurine on oxidized fish-oil-induced liver oxidative stress and intestinal barrier-function impairment in juvenile <i>ictalurus punctatus</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/80d47c3dfe5f42be8e01a724863d22ca
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The Protective Effect of Taurine on Oxidized Fish-Oil-Induced Liver Oxidative Stress and Intestinal Barrier-Function Impairment in Juvenile <i>Ictalurus punctatus</i>

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