MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL

Nakabayashi et al find that the E3 ligase MIB2 ubiquitylates the apoptosis-inhibitor cFLIP and that deletion of MIB2 enhances both RIPK1 kinase-dependent and -independent apoptosis through an increase in RIPK1 kinase activity and impairment of ubiquitylation of cFLIPL, respectively.

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Autores principales:	Osamu Nakabayashi, Hirotaka Takahashi, Kenta Moriwaki, Sachiko Komazawa-Sakon, Fumiaki Ohtake, Shin Murai, Yuichi Tsuchiya, Yuki Koyahara, Yasushi Saeki, Yukiko Yoshida, Soh Yamazaki, Fuminori Tokunaga, Tatsuya Sawasaki, Hiroyasu Nakano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/80d5d42aecbe4fc38a635136494386c1
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spelling	oai:doaj.org-article:80d5d42aecbe4fc38a635136494386c12021-12-02T11:50:30ZMIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL10.1038/s42003-020-01603-y2399-3642https://doaj.org/article/80d5d42aecbe4fc38a635136494386c12021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01603-yhttps://doaj.org/toc/2399-3642Nakabayashi et al find that the E3 ligase MIB2 ubiquitylates the apoptosis-inhibitor cFLIP and that deletion of MIB2 enhances both RIPK1 kinase-dependent and -independent apoptosis through an increase in RIPK1 kinase activity and impairment of ubiquitylation of cFLIPL, respectively.Osamu NakabayashiHirotaka TakahashiKenta MoriwakiSachiko Komazawa-SakonFumiaki OhtakeShin MuraiYuichi TsuchiyaYuki KoyaharaYasushi SaekiYukiko YoshidaSoh YamazakiFuminori TokunagaTatsuya SawasakiHiroyasu NakanoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Osamu Nakabayashi Hirotaka Takahashi Kenta Moriwaki Sachiko Komazawa-Sakon Fumiaki Ohtake Shin Murai Yuichi Tsuchiya Yuki Koyahara Yasushi Saeki Yukiko Yoshida Soh Yamazaki Fuminori Tokunaga Tatsuya Sawasaki Hiroyasu Nakano MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL
description	Nakabayashi et al find that the E3 ligase MIB2 ubiquitylates the apoptosis-inhibitor cFLIP and that deletion of MIB2 enhances both RIPK1 kinase-dependent and -independent apoptosis through an increase in RIPK1 kinase activity and impairment of ubiquitylation of cFLIPL, respectively.
format	article
author	Osamu Nakabayashi Hirotaka Takahashi Kenta Moriwaki Sachiko Komazawa-Sakon Fumiaki Ohtake Shin Murai Yuichi Tsuchiya Yuki Koyahara Yasushi Saeki Yukiko Yoshida Soh Yamazaki Fuminori Tokunaga Tatsuya Sawasaki Hiroyasu Nakano
author_facet	Osamu Nakabayashi Hirotaka Takahashi Kenta Moriwaki Sachiko Komazawa-Sakon Fumiaki Ohtake Shin Murai Yuichi Tsuchiya Yuki Koyahara Yasushi Saeki Yukiko Yoshida Soh Yamazaki Fuminori Tokunaga Tatsuya Sawasaki Hiroyasu Nakano
author_sort	Osamu Nakabayashi
title	MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL
title_short	MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL
title_full	MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL
title_fullStr	MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL
title_full_unstemmed	MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL
title_sort	mind bomb 2 prevents ripk1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cflipl
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/80d5d42aecbe4fc38a635136494386c1
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MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL

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