Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes
Astrocytes are important players in brain development, homeostasis, and disease. Here, the authors compare the transcriptional profiles of human and mouse astrocytes. They report species-specific susceptibility to oxidative stress and response to hypoxic and inflammatory conditions.
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/80da4dfa224845c2a806b159e42df65d |
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oai:doaj.org-article:80da4dfa224845c2a806b159e42df65d2021-12-02T16:06:03ZConservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes10.1038/s41467-021-24232-32041-1723https://doaj.org/article/80da4dfa224845c2a806b159e42df65d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24232-3https://doaj.org/toc/2041-1723Astrocytes are important players in brain development, homeostasis, and disease. Here, the authors compare the transcriptional profiles of human and mouse astrocytes. They report species-specific susceptibility to oxidative stress and response to hypoxic and inflammatory conditions.Jiwen LiLin PanWilliam G. PembrokeJessica E. RexachMarlesa I. GodoyMichael C. CondroAlvaro G. AlvaradoMineli HarteniYen-Wei ChenLinsey StilesAngela Y. ChenIna B. WannerXia YangSteven A. GoldmanDaniel H. GeschwindHarley I. KornblumYe ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jiwen Li Lin Pan William G. Pembroke Jessica E. Rexach Marlesa I. Godoy Michael C. Condro Alvaro G. Alvarado Mineli Harteni Yen-Wei Chen Linsey Stiles Angela Y. Chen Ina B. Wanner Xia Yang Steven A. Goldman Daniel H. Geschwind Harley I. Kornblum Ye Zhang Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes |
| description |
Astrocytes are important players in brain development, homeostasis, and disease. Here, the authors compare the transcriptional profiles of human and mouse astrocytes. They report species-specific susceptibility to oxidative stress and response to hypoxic and inflammatory conditions. |
| format |
article |
| author |
Jiwen Li Lin Pan William G. Pembroke Jessica E. Rexach Marlesa I. Godoy Michael C. Condro Alvaro G. Alvarado Mineli Harteni Yen-Wei Chen Linsey Stiles Angela Y. Chen Ina B. Wanner Xia Yang Steven A. Goldman Daniel H. Geschwind Harley I. Kornblum Ye Zhang |
| author_facet |
Jiwen Li Lin Pan William G. Pembroke Jessica E. Rexach Marlesa I. Godoy Michael C. Condro Alvaro G. Alvarado Mineli Harteni Yen-Wei Chen Linsey Stiles Angela Y. Chen Ina B. Wanner Xia Yang Steven A. Goldman Daniel H. Geschwind Harley I. Kornblum Ye Zhang |
| author_sort |
Jiwen Li |
| title |
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes |
| title_short |
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes |
| title_full |
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes |
| title_fullStr |
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes |
| title_full_unstemmed |
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes |
| title_sort |
conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/80da4dfa224845c2a806b159e42df65d |
| work_keys_str_mv |
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| _version_ |
1718385157579210752 |