The Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats

ABSTRACT Background: Obesity is a disorder or disease characterized by the accumulation of excess fat in the body due to an imbalance in energy intake that is used for a long time. Accumulation of fat can reduce adiponectin, causing cardiac hypertrophy, endothelial vasodilation, and other cardiovas...

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Autores principales:	Andreas Arie Setiawan, Fairuz Azmila Purnomo, Vega Karlowee, Noor Wijayahadi
Formato:	article
Lenguaje:	EN
Publicado:	Diponegoro University 2021
Materias:	black garlic, obesity heart and aortic histopathology Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/80dccffed8b1420cad8a337f70a93bc6
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spelling	oai:doaj.org-article:80dccffed8b1420cad8a337f70a93bc62021-11-05T16:47:51ZThe Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats2503-217810.14710/jbtr.v7i2.11686https://doaj.org/article/80dccffed8b1420cad8a337f70a93bc62021-08-01T00:00:00Zhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/11686https://doaj.org/toc/2503-2178ABSTRACT Background: Obesity is a disorder or disease characterized by the accumulation of excess fat in the body due to an imbalance in energy intake that is used for a long time. Accumulation of fat can reduce adiponectin, causing cardiac hypertrophy, endothelial vasodilation, and other cardiovascular diseases. Black garlic have high antioxidants in the form of S-Allylcysteine(SAC) which functions to increase adiponectin. Objective: To determine the effect of Black garlic on the histopathological picture of the heart and aorta of obese rats. Methods: This study was an experimental study with a randomized post-test only design with control group design with 5 groups of male white rats Sprague Dawley (Rattus novergicus) fed High Fat Fructose. Diet (HFFD) enriched with 1.25% cholesterol and 0.5% cholic acid for 8 weeks and was given black garlic intervention at doses of 450 mg / 200BW, 900mg / 200BW and 1350mg200 / BW for 4 weeks. Results: Giving black garlic significantly reduced body weight of rats (p = 0.001), and the results did not significantly reduce heart weight (p = 0.147), aortic weight (p = 0.061), histopathological changes in heart wall thickness (p = 0.423) and aortic wall thickness (p = 0.802). The effective doses of black garlic in this study were 450 mg / 200 grams BW, 900 mg / 200 grams rat BW and 1350 mg / 200 grams BW of rats. The optimal dose is 900 mg / 200 grams BW. Conclusion: Black garlic gave a significant reduction in body weight of rats and no significant reduction in heart weight, aortic weight, cardiac and aortic histopathological features.Andreas Arie SetiawanFairuz Azmila PurnomoVega KarloweeNoor WijayahadiDiponegoro Universityarticleblack garlic,obesityheart and aortic histopathologyMedicine (General)R5-920ENJournal of Biomedicine and Translational Research, Vol 7, Iss 2, Pp 62-68 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	black garlic, obesity heart and aortic histopathology Medicine (General) R5-920
spellingShingle	black garlic, obesity heart and aortic histopathology Medicine (General) R5-920 Andreas Arie Setiawan Fairuz Azmila Purnomo Vega Karlowee Noor Wijayahadi The Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats
description	ABSTRACT Background: Obesity is a disorder or disease characterized by the accumulation of excess fat in the body due to an imbalance in energy intake that is used for a long time. Accumulation of fat can reduce adiponectin, causing cardiac hypertrophy, endothelial vasodilation, and other cardiovascular diseases. Black garlic have high antioxidants in the form of S-Allylcysteine(SAC) which functions to increase adiponectin. Objective: To determine the effect of Black garlic on the histopathological picture of the heart and aorta of obese rats. Methods: This study was an experimental study with a randomized post-test only design with control group design with 5 groups of male white rats Sprague Dawley (Rattus novergicus) fed High Fat Fructose. Diet (HFFD) enriched with 1.25% cholesterol and 0.5% cholic acid for 8 weeks and was given black garlic intervention at doses of 450 mg / 200BW, 900mg / 200BW and 1350mg200 / BW for 4 weeks. Results: Giving black garlic significantly reduced body weight of rats (p = 0.001), and the results did not significantly reduce heart weight (p = 0.147), aortic weight (p = 0.061), histopathological changes in heart wall thickness (p = 0.423) and aortic wall thickness (p = 0.802). The effective doses of black garlic in this study were 450 mg / 200 grams BW, 900 mg / 200 grams rat BW and 1350 mg / 200 grams BW of rats. The optimal dose is 900 mg / 200 grams BW. Conclusion: Black garlic gave a significant reduction in body weight of rats and no significant reduction in heart weight, aortic weight, cardiac and aortic histopathological features.
format	article
author	Andreas Arie Setiawan Fairuz Azmila Purnomo Vega Karlowee Noor Wijayahadi
author_facet	Andreas Arie Setiawan Fairuz Azmila Purnomo Vega Karlowee Noor Wijayahadi
author_sort	Andreas Arie Setiawan
title	The Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats
title_short	The Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats
title_full	The Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats
title_fullStr	The Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats
title_full_unstemmed	The Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats
title_sort	effect of black garlic (allium sativum linn) on cardiac and aortic histopathology in experimental studies in obesity rats
publisher	Diponegoro University
publishDate	2021
url	https://doaj.org/article/80dccffed8b1420cad8a337f70a93bc6
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The Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats

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