Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid

Abstract Metronomic photodynamic therapy (mPDT) is a form of PDT that induces cancer cell death by intermittent continuous irradiation with a relatively weak power of light for a long duration (several days). We previously developed a wirelessly powered, fully implantable LED device and reported a s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Izumi Kirino, Katsuhiko Fujita, Kei Sakanoue, Rin Sugita, Kento Yamagishi, Shinji Takeoka, Toshinori Fujie, Shinji Uemoto, Yuji Morimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/80de1a88c26848e78d07e62b968d96ef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:80de1a88c26848e78d07e62b968d96ef
record_format	dspace
spelling	oai:doaj.org-article:80de1a88c26848e78d07e62b968d96ef2021-12-02T11:57:56ZMetronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid10.1038/s41598-020-79067-72045-2322https://doaj.org/article/80de1a88c26848e78d07e62b968d96ef2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79067-7https://doaj.org/toc/2045-2322Abstract Metronomic photodynamic therapy (mPDT) is a form of PDT that induces cancer cell death by intermittent continuous irradiation with a relatively weak power of light for a long duration (several days). We previously developed a wirelessly powered, fully implantable LED device and reported a significant anti-tumor effect of mPDT. Considering application in clinical practice, the method used for repeated administrations of photosensitizers required for mPDT should not have a high patient burden such as the burden of transvenous administration. Therefore, in this study, we selected 5-aminolevulinic acid (ALA), which can be administered orally, as a photosensitizer, and we studied the antitumor effects of mPDT. In mice with intradermal tumors that were orally administered ALA (200 mg/kg daily for 5 days), the tumor in each mouse was simultaneously irradiated (8 h/day for 5 days) using a wirelessly powered implantable green LED device (532 nm, 0.05 mW). Tumor growth in the mPDT-treated mice was suppressed by about half compared to that in untreated mice. The results showed that mPDT using the wirelessly powered implantable LED device exerted an antitumor effect even with the use of orally administered ALA, and this treatment scheme can reduce the burden of photosensitizer administration for a patient.Izumi KirinoKatsuhiko FujitaKei SakanoueRin SugitaKento YamagishiShinji TakeokaToshinori FujieShinji UemotoYuji MorimotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Izumi Kirino Katsuhiko Fujita Kei Sakanoue Rin Sugita Kento Yamagishi Shinji Takeoka Toshinori Fujie Shinji Uemoto Yuji Morimoto Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid
description	Abstract Metronomic photodynamic therapy (mPDT) is a form of PDT that induces cancer cell death by intermittent continuous irradiation with a relatively weak power of light for a long duration (several days). We previously developed a wirelessly powered, fully implantable LED device and reported a significant anti-tumor effect of mPDT. Considering application in clinical practice, the method used for repeated administrations of photosensitizers required for mPDT should not have a high patient burden such as the burden of transvenous administration. Therefore, in this study, we selected 5-aminolevulinic acid (ALA), which can be administered orally, as a photosensitizer, and we studied the antitumor effects of mPDT. In mice with intradermal tumors that were orally administered ALA (200 mg/kg daily for 5 days), the tumor in each mouse was simultaneously irradiated (8 h/day for 5 days) using a wirelessly powered implantable green LED device (532 nm, 0.05 mW). Tumor growth in the mPDT-treated mice was suppressed by about half compared to that in untreated mice. The results showed that mPDT using the wirelessly powered implantable LED device exerted an antitumor effect even with the use of orally administered ALA, and this treatment scheme can reduce the burden of photosensitizer administration for a patient.
format	article
author	Izumi Kirino Katsuhiko Fujita Kei Sakanoue Rin Sugita Kento Yamagishi Shinji Takeoka Toshinori Fujie Shinji Uemoto Yuji Morimoto
author_facet	Izumi Kirino Katsuhiko Fujita Kei Sakanoue Rin Sugita Kento Yamagishi Shinji Takeoka Toshinori Fujie Shinji Uemoto Yuji Morimoto
author_sort	Izumi Kirino
title	Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid
title_short	Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid
title_full	Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid
title_fullStr	Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid
title_full_unstemmed	Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid
title_sort	metronomic photodynamic therapy using an implantable led device and orally administered 5-aminolevulinic acid
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/80de1a88c26848e78d07e62b968d96ef
work_keys_str_mv	AT izumikirino metronomicphotodynamictherapyusinganimplantableleddeviceandorallyadministered5aminolevulinicacid AT katsuhikofujita metronomicphotodynamictherapyusinganimplantableleddeviceandorallyadministered5aminolevulinicacid AT keisakanoue metronomicphotodynamictherapyusinganimplantableleddeviceandorallyadministered5aminolevulinicacid AT rinsugita metronomicphotodynamictherapyusinganimplantableleddeviceandorallyadministered5aminolevulinicacid AT kentoyamagishi metronomicphotodynamictherapyusinganimplantableleddeviceandorallyadministered5aminolevulinicacid AT shinjitakeoka metronomicphotodynamictherapyusinganimplantableleddeviceandorallyadministered5aminolevulinicacid AT toshinorifujie metronomicphotodynamictherapyusinganimplantableleddeviceandorallyadministered5aminolevulinicacid AT shinjiuemoto metronomicphotodynamictherapyusinganimplantableleddeviceandorallyadministered5aminolevulinicacid AT yujimorimoto metronomicphotodynamictherapyusinganimplantableleddeviceandorallyadministered5aminolevulinicacid
_version_	1718394817272086528

Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid

Ejemplares similares