Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

Claspin mediates the transmission of a replication-stress signal from ATR to Chk1 and is necessary for efficient fork progression. Here the authors demonstrate that the C-terminal acidic patch is important for this role due to its interaction with Cdc7.

Guardado en:
Detalles Bibliográficos
Autores principales: Chi-Chun Yang, Masahiro Suzuki, Shiori Yamakawa, Syuzi Uno, Ai Ishii, Satoshi Yamazaki, Rino Fukatsu, Ryo Fujisawa, Kenji Sakimura, Toshiki Tsurimoto, Hisao Masai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/80ded932439f424cb6a70a103797b95e
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:80ded932439f424cb6a70a103797b95e
record_format dspace
spelling oai:doaj.org-article:80ded932439f424cb6a70a103797b95e2021-12-02T16:57:59ZClaspin recruits Cdc7 kinase for initiation of DNA replication in human cells10.1038/ncomms121352041-1723https://doaj.org/article/80ded932439f424cb6a70a103797b95e2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12135https://doaj.org/toc/2041-1723Claspin mediates the transmission of a replication-stress signal from ATR to Chk1 and is necessary for efficient fork progression. Here the authors demonstrate that the C-terminal acidic patch is important for this role due to its interaction with Cdc7.Chi-Chun YangMasahiro SuzukiShiori YamakawaSyuzi UnoAi IshiiSatoshi YamazakiRino FukatsuRyo FujisawaKenji SakimuraToshiki TsurimotoHisao MasaiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chi-Chun Yang
Masahiro Suzuki
Shiori Yamakawa
Syuzi Uno
Ai Ishii
Satoshi Yamazaki
Rino Fukatsu
Ryo Fujisawa
Kenji Sakimura
Toshiki Tsurimoto
Hisao Masai
Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells
description Claspin mediates the transmission of a replication-stress signal from ATR to Chk1 and is necessary for efficient fork progression. Here the authors demonstrate that the C-terminal acidic patch is important for this role due to its interaction with Cdc7.
format article
author Chi-Chun Yang
Masahiro Suzuki
Shiori Yamakawa
Syuzi Uno
Ai Ishii
Satoshi Yamazaki
Rino Fukatsu
Ryo Fujisawa
Kenji Sakimura
Toshiki Tsurimoto
Hisao Masai
author_facet Chi-Chun Yang
Masahiro Suzuki
Shiori Yamakawa
Syuzi Uno
Ai Ishii
Satoshi Yamazaki
Rino Fukatsu
Ryo Fujisawa
Kenji Sakimura
Toshiki Tsurimoto
Hisao Masai
author_sort Chi-Chun Yang
title Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells
title_short Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells
title_full Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells
title_fullStr Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells
title_full_unstemmed Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells
title_sort claspin recruits cdc7 kinase for initiation of dna replication in human cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/80ded932439f424cb6a70a103797b95e
work_keys_str_mv AT chichunyang claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
AT masahirosuzuki claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
AT shioriyamakawa claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
AT syuziuno claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
AT aiishii claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
AT satoshiyamazaki claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
AT rinofukatsu claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
AT ryofujisawa claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
AT kenjisakimura claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
AT toshikitsurimoto claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
AT hisaomasai claspinrecruitscdc7kinaseforinitiationofdnareplicationinhumancells
_version_ 1718382395904753664

Ejemplares similares