Exocyst dynamics during vesicle tethering and fusion

Exocyst complex tethers vesicles to plasma membranes, but assembly mechanisms remain unclear. Here, the authors use Cas9 gene editing to tag exocyst components in epithelial cells, and find that exocyst subcomplexes are recruited to membranes independently, but are both needed for vesicle fusion.

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Autores principales:	Syed Mukhtar Ahmed, Hisayo Nishida-Fukuda, Yuchong Li, W. Hayes McDonald, Claudiu C. Gradinaru, Ian G. Macara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80e44de8f19547999c48c3abdab08f24
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id	oai:doaj.org-article:80e44de8f19547999c48c3abdab08f24
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spelling	oai:doaj.org-article:80e44de8f19547999c48c3abdab08f242021-12-02T15:34:28ZExocyst dynamics during vesicle tethering and fusion10.1038/s41467-018-07467-52041-1723https://doaj.org/article/80e44de8f19547999c48c3abdab08f242018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07467-5https://doaj.org/toc/2041-1723Exocyst complex tethers vesicles to plasma membranes, but assembly mechanisms remain unclear. Here, the authors use Cas9 gene editing to tag exocyst components in epithelial cells, and find that exocyst subcomplexes are recruited to membranes independently, but are both needed for vesicle fusion.Syed Mukhtar AhmedHisayo Nishida-FukudaYuchong LiW. Hayes McDonaldClaudiu C. GradinaruIan G. MacaraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Syed Mukhtar Ahmed Hisayo Nishida-Fukuda Yuchong Li W. Hayes McDonald Claudiu C. Gradinaru Ian G. Macara Exocyst dynamics during vesicle tethering and fusion
description	Exocyst complex tethers vesicles to plasma membranes, but assembly mechanisms remain unclear. Here, the authors use Cas9 gene editing to tag exocyst components in epithelial cells, and find that exocyst subcomplexes are recruited to membranes independently, but are both needed for vesicle fusion.
format	article
author	Syed Mukhtar Ahmed Hisayo Nishida-Fukuda Yuchong Li W. Hayes McDonald Claudiu C. Gradinaru Ian G. Macara
author_facet	Syed Mukhtar Ahmed Hisayo Nishida-Fukuda Yuchong Li W. Hayes McDonald Claudiu C. Gradinaru Ian G. Macara
author_sort	Syed Mukhtar Ahmed
title	Exocyst dynamics during vesicle tethering and fusion
title_short	Exocyst dynamics during vesicle tethering and fusion
title_full	Exocyst dynamics during vesicle tethering and fusion
title_fullStr	Exocyst dynamics during vesicle tethering and fusion
title_full_unstemmed	Exocyst dynamics during vesicle tethering and fusion
title_sort	exocyst dynamics during vesicle tethering and fusion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/80e44de8f19547999c48c3abdab08f24
work_keys_str_mv	AT syedmukhtarahmed exocystdynamicsduringvesicletetheringandfusion AT hisayonishidafukuda exocystdynamicsduringvesicletetheringandfusion AT yuchongli exocystdynamicsduringvesicletetheringandfusion AT whayesmcdonald exocystdynamicsduringvesicletetheringandfusion AT claudiucgradinaru exocystdynamicsduringvesicletetheringandfusion AT iangmacara exocystdynamicsduringvesicletetheringandfusion
_version_	1718386846248992768

Exocyst dynamics during vesicle tethering and fusion

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