Cerebral and systemic hemodynamic effect of recurring seizures

Abstract The increase in neuronal activity induced by a single seizure is supported by a rise in the cerebral blood flow and tissue oxygenation, a mechanism called neurovascular coupling (NVC). Whether cerebral and systemic hemodynamics are able to match neuronal activity during recurring seizures i...

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Autores principales:	Lorenzo Ferlini, Fuhong Su, Jacques Creteur, Fabio Silvio Taccone, Nicolas Gaspard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/80e4f2329df741d190d9a1c8a8e5a249
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spelling	oai:doaj.org-article:80e4f2329df741d190d9a1c8a8e5a2492021-11-21T12:19:46ZCerebral and systemic hemodynamic effect of recurring seizures10.1038/s41598-021-01704-62045-2322https://doaj.org/article/80e4f2329df741d190d9a1c8a8e5a2492021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01704-6https://doaj.org/toc/2045-2322Abstract The increase in neuronal activity induced by a single seizure is supported by a rise in the cerebral blood flow and tissue oxygenation, a mechanism called neurovascular coupling (NVC). Whether cerebral and systemic hemodynamics are able to match neuronal activity during recurring seizures is unclear, as data from rodent models are at odds with human studies. In order to clarify this issue, we used an invasive brain and systemic monitoring to study the effects of chemically induced non-convulsive seizures in sheep. Despite an increase in neuronal activity as seizures repeat (Spearman’s ρ coefficient 0.31, P < 0.001), ictal variations of cerebral blood flow remained stable while it progressively increased in the inter-ictal intervals (ρ = 0.06, P = 0.44 and ρ = 0.22; P = 0.008). We also observed a progressive reduction in the inter-ictal brain tissue oxygenation (ρ = − 0.18; P = 0.04), suggesting that NVC was unable to compensate for the metabolic demand of these closely repeating seizures. At the systemic level, there was a progressive reduction in blood pressure and a progressive rise in cardiac output (ρ = − 0.22; P = 0.01 and ρ = 0.22; P = 0.01, respectively), suggesting seizure-induced autonomic dysfunction.Lorenzo FerliniFuhong SuJacques CreteurFabio Silvio TacconeNicolas GaspardNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lorenzo Ferlini Fuhong Su Jacques Creteur Fabio Silvio Taccone Nicolas Gaspard Cerebral and systemic hemodynamic effect of recurring seizures
description	Abstract The increase in neuronal activity induced by a single seizure is supported by a rise in the cerebral blood flow and tissue oxygenation, a mechanism called neurovascular coupling (NVC). Whether cerebral and systemic hemodynamics are able to match neuronal activity during recurring seizures is unclear, as data from rodent models are at odds with human studies. In order to clarify this issue, we used an invasive brain and systemic monitoring to study the effects of chemically induced non-convulsive seizures in sheep. Despite an increase in neuronal activity as seizures repeat (Spearman’s ρ coefficient 0.31, P < 0.001), ictal variations of cerebral blood flow remained stable while it progressively increased in the inter-ictal intervals (ρ = 0.06, P = 0.44 and ρ = 0.22; P = 0.008). We also observed a progressive reduction in the inter-ictal brain tissue oxygenation (ρ = − 0.18; P = 0.04), suggesting that NVC was unable to compensate for the metabolic demand of these closely repeating seizures. At the systemic level, there was a progressive reduction in blood pressure and a progressive rise in cardiac output (ρ = − 0.22; P = 0.01 and ρ = 0.22; P = 0.01, respectively), suggesting seizure-induced autonomic dysfunction.
format	article
author	Lorenzo Ferlini Fuhong Su Jacques Creteur Fabio Silvio Taccone Nicolas Gaspard
author_facet	Lorenzo Ferlini Fuhong Su Jacques Creteur Fabio Silvio Taccone Nicolas Gaspard
author_sort	Lorenzo Ferlini
title	Cerebral and systemic hemodynamic effect of recurring seizures
title_short	Cerebral and systemic hemodynamic effect of recurring seizures
title_full	Cerebral and systemic hemodynamic effect of recurring seizures
title_fullStr	Cerebral and systemic hemodynamic effect of recurring seizures
title_full_unstemmed	Cerebral and systemic hemodynamic effect of recurring seizures
title_sort	cerebral and systemic hemodynamic effect of recurring seizures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/80e4f2329df741d190d9a1c8a8e5a249
work_keys_str_mv	AT lorenzoferlini cerebralandsystemichemodynamiceffectofrecurringseizures AT fuhongsu cerebralandsystemichemodynamiceffectofrecurringseizures AT jacquescreteur cerebralandsystemichemodynamiceffectofrecurringseizures AT fabiosilviotaccone cerebralandsystemichemodynamiceffectofrecurringseizures AT nicolasgaspard cerebralandsystemichemodynamiceffectofrecurringseizures
_version_	1718419075465478144

Cerebral and systemic hemodynamic effect of recurring seizures

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