Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti

Ayers et al. report rapid induction of apoptosis in the midgut of Aedes aegypti mosquitoes within 2 hours of infection by dengue and Zika viruses, and find that inhibiting apoptosis led to increased virus proliferation in the midgut. These results suggest rapid induction of apoptosis as an innate im...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jasmine B. Ayers, Heather G. Coatsworth, Seokyoung Kang, Rhoel R. Dinglasan, Lei Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/80e64bfcddae416fad1881095c029b05
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:80e64bfcddae416fad1881095c029b05
record_format	dspace
spelling	oai:doaj.org-article:80e64bfcddae416fad1881095c029b052021-12-02T15:22:54ZClustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti10.1038/s42003-020-01614-92399-3642https://doaj.org/article/80e64bfcddae416fad1881095c029b052021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01614-9https://doaj.org/toc/2399-3642Ayers et al. report rapid induction of apoptosis in the midgut of Aedes aegypti mosquitoes within 2 hours of infection by dengue and Zika viruses, and find that inhibiting apoptosis led to increased virus proliferation in the midgut. These results suggest rapid induction of apoptosis as an innate immune mechanism mediating midgut infection in this mosquito vector.Jasmine B. AyersHeather G. CoatsworthSeokyoung KangRhoel R. DinglasanLei ZhouNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jasmine B. Ayers Heather G. Coatsworth Seokyoung Kang Rhoel R. Dinglasan Lei Zhou Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti
description	Ayers et al. report rapid induction of apoptosis in the midgut of Aedes aegypti mosquitoes within 2 hours of infection by dengue and Zika viruses, and find that inhibiting apoptosis led to increased virus proliferation in the midgut. These results suggest rapid induction of apoptosis as an innate immune mechanism mediating midgut infection in this mosquito vector.
format	article
author	Jasmine B. Ayers Heather G. Coatsworth Seokyoung Kang Rhoel R. Dinglasan Lei Zhou
author_facet	Jasmine B. Ayers Heather G. Coatsworth Seokyoung Kang Rhoel R. Dinglasan Lei Zhou
author_sort	Jasmine B. Ayers
title	Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti
title_short	Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti
title_full	Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti
title_fullStr	Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti
title_full_unstemmed	Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti
title_sort	clustered rapid induction of apoptosis limits zikv and denv-2 proliferation in the midguts of aedes aegypti
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/80e64bfcddae416fad1881095c029b05
work_keys_str_mv	AT jasminebayers clusteredrapidinductionofapoptosislimitszikvanddenv2proliferationinthemidgutsofaedesaegypti AT heathergcoatsworth clusteredrapidinductionofapoptosislimitszikvanddenv2proliferationinthemidgutsofaedesaegypti AT seokyoungkang clusteredrapidinductionofapoptosislimitszikvanddenv2proliferationinthemidgutsofaedesaegypti AT rhoelrdinglasan clusteredrapidinductionofapoptosislimitszikvanddenv2proliferationinthemidgutsofaedesaegypti AT leizhou clusteredrapidinductionofapoptosislimitszikvanddenv2proliferationinthemidgutsofaedesaegypti
_version_	1718387389035970560

Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti

Ejemplares similares