Association between hypogonadism and reproductive tissue steroid-producing cells antibody in men with positive MAR test IgG and diabetes mellitus type 1

BACKGROUND: Autoimmune hypogonadism is frequently taped in men with positive direct mixed agglutination reaction antisperm antibodies IgG test (MAR test IgG). AIMS: Тo assess pathogenetic factor of autoimmune hypogonadism in men with positive MAR test IgG and diabetes mellitus type 1 (DM1). MATERI...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Roman V. Rozhivanov, Irina I. Vitiazeva
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2019
Materias:	hypogonadism men autoimmune testosterone diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/80e9c84e197b4efcbdf8a4840cf61904
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:80e9c84e197b4efcbdf8a4840cf61904
record_format	dspace
spelling	oai:doaj.org-article:80e9c84e197b4efcbdf8a4840cf619042021-11-14T09:00:22ZAssociation between hypogonadism and reproductive tissue steroid-producing cells antibody in men with positive MAR test IgG and diabetes mellitus type 12072-03512072-037810.14341/DM10102https://doaj.org/article/80e9c84e197b4efcbdf8a4840cf619042019-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10102https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378BACKGROUND: Autoimmune hypogonadism is frequently taped in men with positive direct mixed agglutination reaction antisperm antibodies IgG test (MAR test IgG). AIMS: Тo assess pathogenetic factor of autoimmune hypogonadism in men with positive MAR test IgG and diabetes mellitus type 1 (DM1). MATERIALS AND METHODS: A retrospective study included 97 patients with positive direct MAR test IgG: 30 men with DM1 and 67 – without DM. Assessment included testosterone level and titer of summary reproductive tissue steroid-producing cells antibody (LCA). Statistically significant differences were p<0,05. RESULTS: 43% of men with DM1 have abnormal LCA titer and it was significantly higher than in patients without DM – 21%. In both groups testosterone level was significantly lower in men with abnormal LCA titer than in patients with normal antibodies titer. Frequency of hypogonadism in men with abnormal LCA titer was significantly higher than in patients with normal antibodies titer also in both groups. There were no significantly differences of MAR test IgG in patients with normal and abnormal LCA titer. CONCLUSIONS: Autoimmune hypogonadism is a common complication in men with DM1 and positive MAR test IgG and it’s strongly associated with high titer of summary reproductive tissue steroid-producing cells antibody.Roman V. RozhivanovIrina I. VitiazevaEndocrinology Research Centrearticlehypogonadismmenautoimmunetestosteronediabetes mellitusNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 22, Iss 5, Pp 444-447 (2019)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	hypogonadism men autoimmune testosterone diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	hypogonadism men autoimmune testosterone diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627 Roman V. Rozhivanov Irina I. Vitiazeva Association between hypogonadism and reproductive tissue steroid-producing cells antibody in men with positive MAR test IgG and diabetes mellitus type 1
description	BACKGROUND: Autoimmune hypogonadism is frequently taped in men with positive direct mixed agglutination reaction antisperm antibodies IgG test (MAR test IgG). AIMS: Тo assess pathogenetic factor of autoimmune hypogonadism in men with positive MAR test IgG and diabetes mellitus type 1 (DM1). MATERIALS AND METHODS: A retrospective study included 97 patients with positive direct MAR test IgG: 30 men with DM1 and 67 – without DM. Assessment included testosterone level and titer of summary reproductive tissue steroid-producing cells antibody (LCA). Statistically significant differences were p<0,05. RESULTS: 43% of men with DM1 have abnormal LCA titer and it was significantly higher than in patients without DM – 21%. In both groups testosterone level was significantly lower in men with abnormal LCA titer than in patients with normal antibodies titer. Frequency of hypogonadism in men with abnormal LCA titer was significantly higher than in patients with normal antibodies titer also in both groups. There were no significantly differences of MAR test IgG in patients with normal and abnormal LCA titer. CONCLUSIONS: Autoimmune hypogonadism is a common complication in men with DM1 and positive MAR test IgG and it’s strongly associated with high titer of summary reproductive tissue steroid-producing cells antibody.
format	article
author	Roman V. Rozhivanov Irina I. Vitiazeva
author_facet	Roman V. Rozhivanov Irina I. Vitiazeva
author_sort	Roman V. Rozhivanov
title	Association between hypogonadism and reproductive tissue steroid-producing cells antibody in men with positive MAR test IgG and diabetes mellitus type 1
title_short	Association between hypogonadism and reproductive tissue steroid-producing cells antibody in men with positive MAR test IgG and diabetes mellitus type 1
title_full	Association between hypogonadism and reproductive tissue steroid-producing cells antibody in men with positive MAR test IgG and diabetes mellitus type 1
title_fullStr	Association between hypogonadism and reproductive tissue steroid-producing cells antibody in men with positive MAR test IgG and diabetes mellitus type 1
title_full_unstemmed	Association between hypogonadism and reproductive tissue steroid-producing cells antibody in men with positive MAR test IgG and diabetes mellitus type 1
title_sort	association between hypogonadism and reproductive tissue steroid-producing cells antibody in men with positive mar test igg and diabetes mellitus type 1
publisher	Endocrinology Research Centre
publishDate	2019
url	https://doaj.org/article/80e9c84e197b4efcbdf8a4840cf61904
work_keys_str_mv	AT romanvrozhivanov associationbetweenhypogonadismandreproductivetissuesteroidproducingcellsantibodyinmenwithpositivemartestigganddiabetesmellitustype1 AT irinaivitiazeva associationbetweenhypogonadismandreproductivetissuesteroidproducingcellsantibodyinmenwithpositivemartestigganddiabetesmellitustype1
_version_	1718429472239124480

Association between hypogonadism and reproductive tissue steroid-producing cells antibody in men with positive MAR test IgG and diabetes mellitus type 1

Ejemplares similares