MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO
The objective of this research is a bioadhesive two layers controlled release tablets. The drug release and the physical properties of tablet formulations using two polymers (Carrageenan 934 and Eudragit RL PO) at three levels and at a combination of different ratios of the two polymers were e...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Universidad de Antioquia
2009
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/80e9f4ca6b6749d4880ca14fe116d7f2 |
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| Sumario: | The objective of this research is a bioadhesive two layers controlled release tablets. The drug
release and the physical properties of tablet formulations using two polymers (Carrageenan 934
and Eudragit RL PO) at three levels and at a combination of different ratios of the two polymers
were evaluated. Formulation containing 40% total polymer level and a ratio of 1 Carrageenan to
1 Eudragit RLPO was the best formulationa. This formulation was tested in different dissolution
medium and at different rotational speed. The drug release was 96.3% in phosphate buffer pH
7.4; 59.1% in 0.1 N HCl and 46.4% in distilled water.
This study demonstrates the significance of the combination of two polymers for obtaining
controlled release bioadhesive matrix and enhancing the characteristic of each polymer.
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