MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO

The objective of this research is a bioadhesive two layers controlled release tablets. The drug release and the physical properties of tablet formulations using two polymers (Carrageenan 934 and Eudragit RL PO) at three levels and at a combination of different ratios of the two polymers were e...

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Autores principales:	Gloria RUÍZ, Evone S. GHALY
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Carrageenan matrices eudragit RLPO matrices chlorpheniramine maleate bioadhesion sustained release controlled release Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/80e9f4ca6b6749d4880ca14fe116d7f2
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id	oai:doaj.org-article:80e9f4ca6b6749d4880ca14fe116d7f2
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spelling	oai:doaj.org-article:80e9f4ca6b6749d4880ca14fe116d7f22021-11-19T04:22:38ZMUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO0121-40042145-2660https://doaj.org/article/80e9f4ca6b6749d4880ca14fe116d7f22009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/508https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 The objective of this research is a bioadhesive two layers controlled release tablets. The drug release and the physical properties of tablet formulations using two polymers (Carrageenan 934 and Eudragit RL PO) at three levels and at a combination of different ratios of the two polymers were evaluated. Formulation containing 40% total polymer level and a ratio of 1 Carrageenan to 1 Eudragit RLPO was the best formulationa. This formulation was tested in different dissolution medium and at different rotational speed. The drug release was 96.3% in phosphate buffer pH 7.4; 59.1% in 0.1 N HCl and 46.4% in distilled water. This study demonstrates the significance of the combination of two polymers for obtaining controlled release bioadhesive matrix and enhancing the characteristic of each polymer. Gloria RUÍZEvone S. GHALYUniversidad de AntioquiaarticleCarrageenan matriceseudragit RLPO matriceschlorpheniramine maleatebioadhesionsustained releasecontrolled releaseFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 13, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Carrageenan matrices eudragit RLPO matrices chlorpheniramine maleate bioadhesion sustained release controlled release Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Carrageenan matrices eudragit RLPO matrices chlorpheniramine maleate bioadhesion sustained release controlled release Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Gloria RUÍZ Evone S. GHALY MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO
description	The objective of this research is a bioadhesive two layers controlled release tablets. The drug release and the physical properties of tablet formulations using two polymers (Carrageenan 934 and Eudragit RL PO) at three levels and at a combination of different ratios of the two polymers were evaluated. Formulation containing 40% total polymer level and a ratio of 1 Carrageenan to 1 Eudragit RLPO was the best formulationa. This formulation was tested in different dissolution medium and at different rotational speed. The drug release was 96.3% in phosphate buffer pH 7.4; 59.1% in 0.1 N HCl and 46.4% in distilled water. This study demonstrates the significance of the combination of two polymers for obtaining controlled release bioadhesive matrix and enhancing the characteristic of each polymer.
format	article
author	Gloria RUÍZ Evone S. GHALY
author_facet	Gloria RUÍZ Evone S. GHALY
author_sort	Gloria RUÍZ
title	MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO
title_short	MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO
title_full	MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO
title_fullStr	MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO
title_full_unstemmed	MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO
title_sort	mucoadhesive delivery systems using carrageenan and eudragit rlpo
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/80e9f4ca6b6749d4880ca14fe116d7f2
work_keys_str_mv	AT gloriaruiz mucoadhesivedeliverysystemsusingcarrageenanandeudragitrlpo AT evonesghaly mucoadhesivedeliverysystemsusingcarrageenanandeudragitrlpo
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MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO

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