Disorganization of intercalated discs in dilated cardiomyopathy

Abstract Dilated cardiomyopathy (DCM) is a primary myocardial disease, the pathology of which is left ventricular or biventricular dilation and impaired myocardial contractility. The clinical and pathological diagnosis of DCM is difficult, and other cardiac diseases must be ruled out. Several studie...

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Autores principales:	Yukinobu Ito, Makoto Yoshida, Hirotake Masuda, Daichi Maeda, Yukitsugu Kudo-Asabe, Michinobu Umakoshi, Hiroshi Nanjo, Akiteru Goto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/80eaa74311bc4a5e9b9b27bb253c463e
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spelling	oai:doaj.org-article:80eaa74311bc4a5e9b9b27bb253c463e2021-12-02T17:50:49ZDisorganization of intercalated discs in dilated cardiomyopathy10.1038/s41598-021-90502-12045-2322https://doaj.org/article/80eaa74311bc4a5e9b9b27bb253c463e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90502-1https://doaj.org/toc/2045-2322Abstract Dilated cardiomyopathy (DCM) is a primary myocardial disease, the pathology of which is left ventricular or biventricular dilation and impaired myocardial contractility. The clinical and pathological diagnosis of DCM is difficult, and other cardiac diseases must be ruled out. Several studies have reported pathological findings that are characteristic of DCM, including cardiomyocyte atrophy, nuclear pleomorphism, and interstitial fibrosis, but none of these findings are DCM-specific. In this study, we examined the morphological differences in the intercalated discs (ICDs) between three groups of patients, a DCM group, a chronic heart failure group, and a control group. A total of 22 autopsy cases, including five DCM cases, nine CHF cases and eight control cases, were retrieved from the archives of the Department of Pathology at Akita University, Japan. The morphological differences were examined using multiple methods: macroscopic examination, light microscopy, immunohistochemistry, electron microscopy, and gene expression analyses. We observed disorganized ICDs, clearly illustrated by N-cadherin immunostaining in the DCM group. “Reduction of N-cadherin immunostaining intensity” and “ICD scattering” was DCM-specific. The results suggest that disorganized ICDs contribute to the development of DCM, and that N-cadherin immunostaining is useful for determining the presence of disorganized ICDs and for the pathological diagnosis of DCM.Yukinobu ItoMakoto YoshidaHirotake MasudaDaichi MaedaYukitsugu Kudo-AsabeMichinobu UmakoshiHiroshi NanjoAkiteru GotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yukinobu Ito Makoto Yoshida Hirotake Masuda Daichi Maeda Yukitsugu Kudo-Asabe Michinobu Umakoshi Hiroshi Nanjo Akiteru Goto Disorganization of intercalated discs in dilated cardiomyopathy
description	Abstract Dilated cardiomyopathy (DCM) is a primary myocardial disease, the pathology of which is left ventricular or biventricular dilation and impaired myocardial contractility. The clinical and pathological diagnosis of DCM is difficult, and other cardiac diseases must be ruled out. Several studies have reported pathological findings that are characteristic of DCM, including cardiomyocyte atrophy, nuclear pleomorphism, and interstitial fibrosis, but none of these findings are DCM-specific. In this study, we examined the morphological differences in the intercalated discs (ICDs) between three groups of patients, a DCM group, a chronic heart failure group, and a control group. A total of 22 autopsy cases, including five DCM cases, nine CHF cases and eight control cases, were retrieved from the archives of the Department of Pathology at Akita University, Japan. The morphological differences were examined using multiple methods: macroscopic examination, light microscopy, immunohistochemistry, electron microscopy, and gene expression analyses. We observed disorganized ICDs, clearly illustrated by N-cadherin immunostaining in the DCM group. “Reduction of N-cadherin immunostaining intensity” and “ICD scattering” was DCM-specific. The results suggest that disorganized ICDs contribute to the development of DCM, and that N-cadherin immunostaining is useful for determining the presence of disorganized ICDs and for the pathological diagnosis of DCM.
format	article
author	Yukinobu Ito Makoto Yoshida Hirotake Masuda Daichi Maeda Yukitsugu Kudo-Asabe Michinobu Umakoshi Hiroshi Nanjo Akiteru Goto
author_facet	Yukinobu Ito Makoto Yoshida Hirotake Masuda Daichi Maeda Yukitsugu Kudo-Asabe Michinobu Umakoshi Hiroshi Nanjo Akiteru Goto
author_sort	Yukinobu Ito
title	Disorganization of intercalated discs in dilated cardiomyopathy
title_short	Disorganization of intercalated discs in dilated cardiomyopathy
title_full	Disorganization of intercalated discs in dilated cardiomyopathy
title_fullStr	Disorganization of intercalated discs in dilated cardiomyopathy
title_full_unstemmed	Disorganization of intercalated discs in dilated cardiomyopathy
title_sort	disorganization of intercalated discs in dilated cardiomyopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/80eaa74311bc4a5e9b9b27bb253c463e
work_keys_str_mv	AT yukinobuito disorganizationofintercalateddiscsindilatedcardiomyopathy AT makotoyoshida disorganizationofintercalateddiscsindilatedcardiomyopathy AT hirotakemasuda disorganizationofintercalateddiscsindilatedcardiomyopathy AT daichimaeda disorganizationofintercalateddiscsindilatedcardiomyopathy AT yukitsugukudoasabe disorganizationofintercalateddiscsindilatedcardiomyopathy AT michinobuumakoshi disorganizationofintercalateddiscsindilatedcardiomyopathy AT hiroshinanjo disorganizationofintercalateddiscsindilatedcardiomyopathy AT akiterugoto disorganizationofintercalateddiscsindilatedcardiomyopathy
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Disorganization of intercalated discs in dilated cardiomyopathy

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