SLPI is a critical mediator that controls PTH-induced bone formation

The mechanism by which parathyroid hormone mediates the switch from bone resorption to bone formation is unclear. Here, the authors show that SLPI regulates the communication between osteoblasts and osteoclasts to promote the anabolic effect of parathyroid hormone.

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Autores principales:	Akito Morimoto, Junichi Kikuta, Keizo Nishikawa, Takao Sudo, Maki Uenaka, Masayuki Furuya, Tetsuo Hasegawa, Kunihiko Hashimoto, Hiroyuki Tsukazaki, Shigeto Seno, Akira Nakamura, Daisuke Okuzaki, Fuminori Sugihara, Akinori Ninomiya, Takeshi Yoshimura, Ryoko Takao-Kawabata, Hideo Matsuda, Masaru Ishii
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80eb5385981346dea70479fd2d735e0d
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spelling	oai:doaj.org-article:80eb5385981346dea70479fd2d735e0d2021-12-02T14:37:37ZSLPI is a critical mediator that controls PTH-induced bone formation10.1038/s41467-021-22402-x2041-1723https://doaj.org/article/80eb5385981346dea70479fd2d735e0d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22402-xhttps://doaj.org/toc/2041-1723The mechanism by which parathyroid hormone mediates the switch from bone resorption to bone formation is unclear. Here, the authors show that SLPI regulates the communication between osteoblasts and osteoclasts to promote the anabolic effect of parathyroid hormone.Akito MorimotoJunichi KikutaKeizo NishikawaTakao SudoMaki UenakaMasayuki FuruyaTetsuo HasegawaKunihiko HashimotoHiroyuki TsukazakiShigeto SenoAkira NakamuraDaisuke OkuzakiFuminori SugiharaAkinori NinomiyaTakeshi YoshimuraRyoko Takao-KawabataHideo MatsudaMasaru IshiiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Akito Morimoto Junichi Kikuta Keizo Nishikawa Takao Sudo Maki Uenaka Masayuki Furuya Tetsuo Hasegawa Kunihiko Hashimoto Hiroyuki Tsukazaki Shigeto Seno Akira Nakamura Daisuke Okuzaki Fuminori Sugihara Akinori Ninomiya Takeshi Yoshimura Ryoko Takao-Kawabata Hideo Matsuda Masaru Ishii SLPI is a critical mediator that controls PTH-induced bone formation
description	The mechanism by which parathyroid hormone mediates the switch from bone resorption to bone formation is unclear. Here, the authors show that SLPI regulates the communication between osteoblasts and osteoclasts to promote the anabolic effect of parathyroid hormone.
format	article
author	Akito Morimoto Junichi Kikuta Keizo Nishikawa Takao Sudo Maki Uenaka Masayuki Furuya Tetsuo Hasegawa Kunihiko Hashimoto Hiroyuki Tsukazaki Shigeto Seno Akira Nakamura Daisuke Okuzaki Fuminori Sugihara Akinori Ninomiya Takeshi Yoshimura Ryoko Takao-Kawabata Hideo Matsuda Masaru Ishii
author_facet	Akito Morimoto Junichi Kikuta Keizo Nishikawa Takao Sudo Maki Uenaka Masayuki Furuya Tetsuo Hasegawa Kunihiko Hashimoto Hiroyuki Tsukazaki Shigeto Seno Akira Nakamura Daisuke Okuzaki Fuminori Sugihara Akinori Ninomiya Takeshi Yoshimura Ryoko Takao-Kawabata Hideo Matsuda Masaru Ishii
author_sort	Akito Morimoto
title	SLPI is a critical mediator that controls PTH-induced bone formation
title_short	SLPI is a critical mediator that controls PTH-induced bone formation
title_full	SLPI is a critical mediator that controls PTH-induced bone formation
title_fullStr	SLPI is a critical mediator that controls PTH-induced bone formation
title_full_unstemmed	SLPI is a critical mediator that controls PTH-induced bone formation
title_sort	slpi is a critical mediator that controls pth-induced bone formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/80eb5385981346dea70479fd2d735e0d
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SLPI is a critical mediator that controls PTH-induced bone formation

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