The Identification of RNA Modification Gene <i>PUS7</i> as a Potential Biomarker of Ovarian Cancer

RNA modifications are reversible, dynamically regulated, and involved in a variety of diseases such as cancers. Given the lack of efficient and reliable biomarkers for early diagnosis of ovarian cancer (OV), this study was designed to explore the role of RNA modification genes (RMGs) in the diagnosi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huimin Li, Lin Chen, Yunsong Han, Fangfang Zhang, Yanyan Wang, Yali Han, Yange Wang, Qiang Wang, Xiangqian Guo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DEGs diagnosis ovarian cancer PUS7 RMGs Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/80ebc402c1594d459c4fab3fa5182a66
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:80ebc402c1594d459c4fab3fa5182a66
record_format	dspace
spelling	oai:doaj.org-article:80ebc402c1594d459c4fab3fa5182a662021-11-25T16:47:18ZThe Identification of RNA Modification Gene <i>PUS7</i> as a Potential Biomarker of Ovarian Cancer10.3390/biology101111302079-7737https://doaj.org/article/80ebc402c1594d459c4fab3fa5182a662021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1130https://doaj.org/toc/2079-7737RNA modifications are reversible, dynamically regulated, and involved in a variety of diseases such as cancers. Given the lack of efficient and reliable biomarkers for early diagnosis of ovarian cancer (OV), this study was designed to explore the role of RNA modification genes (RMGs) in the diagnosis of OV. Herein, 132 RMGs were retrieved in PubMed, 638 OV and 18 normal ovary samples were retrieved in The Cancer Genome Atlas (TCGA), and GSE18520 cohorts were collected for differential analysis. Finally, <i>PUS7</i> (Pseudouridine Synthase 7) as differentially expressed RMGs (DEGs-RMGs) was identified as a diagnostic biomarker candidate and evaluated for its specificity and sensitivity using Receiver Operating Characteristic (ROC) analysis in TCGA and GEO data. The protein expression, mutation, protein interaction networks, correlated genes, related pathways, biological processes, cell components, and molecular functions of <i>PUS7</i> were analyzed as well. The upregulation of PUS7 protein in OV was confirmed by the staining images in HPA and tissue arrays. Collectively, the findings of the present study point towards the potential of PUS7 as a diagnostic marker and therapeutic target for ovarian cancer.Huimin LiLin ChenYunsong HanFangfang ZhangYanyan WangYali HanYange WangQiang WangXiangqian GuoMDPI AGarticleDEGsdiagnosisovarian cancerPUS7RMGsBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1130, p 1130 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DEGs diagnosis ovarian cancer PUS7 RMGs Biology (General) QH301-705.5
spellingShingle	DEGs diagnosis ovarian cancer PUS7 RMGs Biology (General) QH301-705.5 Huimin Li Lin Chen Yunsong Han Fangfang Zhang Yanyan Wang Yali Han Yange Wang Qiang Wang Xiangqian Guo The Identification of RNA Modification Gene <i>PUS7</i> as a Potential Biomarker of Ovarian Cancer
description	RNA modifications are reversible, dynamically regulated, and involved in a variety of diseases such as cancers. Given the lack of efficient and reliable biomarkers for early diagnosis of ovarian cancer (OV), this study was designed to explore the role of RNA modification genes (RMGs) in the diagnosis of OV. Herein, 132 RMGs were retrieved in PubMed, 638 OV and 18 normal ovary samples were retrieved in The Cancer Genome Atlas (TCGA), and GSE18520 cohorts were collected for differential analysis. Finally, <i>PUS7</i> (Pseudouridine Synthase 7) as differentially expressed RMGs (DEGs-RMGs) was identified as a diagnostic biomarker candidate and evaluated for its specificity and sensitivity using Receiver Operating Characteristic (ROC) analysis in TCGA and GEO data. The protein expression, mutation, protein interaction networks, correlated genes, related pathways, biological processes, cell components, and molecular functions of <i>PUS7</i> were analyzed as well. The upregulation of PUS7 protein in OV was confirmed by the staining images in HPA and tissue arrays. Collectively, the findings of the present study point towards the potential of PUS7 as a diagnostic marker and therapeutic target for ovarian cancer.
format	article
author	Huimin Li Lin Chen Yunsong Han Fangfang Zhang Yanyan Wang Yali Han Yange Wang Qiang Wang Xiangqian Guo
author_facet	Huimin Li Lin Chen Yunsong Han Fangfang Zhang Yanyan Wang Yali Han Yange Wang Qiang Wang Xiangqian Guo
author_sort	Huimin Li
title	The Identification of RNA Modification Gene <i>PUS7</i> as a Potential Biomarker of Ovarian Cancer
title_short	The Identification of RNA Modification Gene <i>PUS7</i> as a Potential Biomarker of Ovarian Cancer
title_full	The Identification of RNA Modification Gene <i>PUS7</i> as a Potential Biomarker of Ovarian Cancer
title_fullStr	The Identification of RNA Modification Gene <i>PUS7</i> as a Potential Biomarker of Ovarian Cancer
title_full_unstemmed	The Identification of RNA Modification Gene <i>PUS7</i> as a Potential Biomarker of Ovarian Cancer
title_sort	identification of rna modification gene <i>pus7</i> as a potential biomarker of ovarian cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/80ebc402c1594d459c4fab3fa5182a66
work_keys_str_mv	AT huiminli theidentificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT linchen theidentificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT yunsonghan theidentificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT fangfangzhang theidentificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT yanyanwang theidentificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT yalihan theidentificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT yangewang theidentificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT qiangwang theidentificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT xiangqianguo theidentificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT huiminli identificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT linchen identificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT yunsonghan identificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT fangfangzhang identificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT yanyanwang identificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT yalihan identificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT yangewang identificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT qiangwang identificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer AT xiangqianguo identificationofrnamodificationgeneipus7iasapotentialbiomarkerofovariancancer
_version_	1718412965934268416

The Identification of RNA Modification Gene <i>PUS7</i> as a Potential Biomarker of Ovarian Cancer

Ejemplares similares