Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

Tumor-associated dendritic cells are defective in their ability to cross-present antigens, and they accumulate lipid bodies. Here the authors show that this defect is due to an impaired trafficking of peptide-MHC class I caused by the interaction of electrophilic lipids with chaperone heat shock pro...

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Autores principales:	Filippo Veglia, Vladimir A. Tyurin, Dariush Mohammadyani, Maria Blasi, Elizabeth K. Duperret, Laxminarasimha Donthireddy, Ayumi Hashimoto, Alexandr Kapralov, Andrew Amoscato, Roberto Angelini, Sima Patel, Kevin Alicea-Torres, David Weiner, Maureen E. Murphy, Judith Klein-Seetharaman, Esteban Celis, Valerian E. Kagan, Dmitry I. Gabrilovich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80f0969ac22343d0a493d691f1f910c0
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spelling	oai:doaj.org-article:80f0969ac22343d0a493d691f1f910c02021-12-02T14:42:23ZLipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer10.1038/s41467-017-02186-92041-1723https://doaj.org/article/80f0969ac22343d0a493d691f1f910c02017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02186-9https://doaj.org/toc/2041-1723Tumor-associated dendritic cells are defective in their ability to cross-present antigens, and they accumulate lipid bodies. Here the authors show that this defect is due to an impaired trafficking of peptide-MHC class I caused by the interaction of electrophilic lipids with chaperone heat shock protein 70.Filippo VegliaVladimir A. TyurinDariush MohammadyaniMaria BlasiElizabeth K. DuperretLaxminarasimha DonthireddyAyumi HashimotoAlexandr KapralovAndrew AmoscatoRoberto AngeliniSima PatelKevin Alicea-TorresDavid WeinerMaureen E. MurphyJudith Klein-SeetharamanEsteban CelisValerian E. KaganDmitry I. GabrilovichNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Filippo Veglia Vladimir A. Tyurin Dariush Mohammadyani Maria Blasi Elizabeth K. Duperret Laxminarasimha Donthireddy Ayumi Hashimoto Alexandr Kapralov Andrew Amoscato Roberto Angelini Sima Patel Kevin Alicea-Torres David Weiner Maureen E. Murphy Judith Klein-Seetharaman Esteban Celis Valerian E. Kagan Dmitry I. Gabrilovich Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
description	Tumor-associated dendritic cells are defective in their ability to cross-present antigens, and they accumulate lipid bodies. Here the authors show that this defect is due to an impaired trafficking of peptide-MHC class I caused by the interaction of electrophilic lipids with chaperone heat shock protein 70.
format	article
author	Filippo Veglia Vladimir A. Tyurin Dariush Mohammadyani Maria Blasi Elizabeth K. Duperret Laxminarasimha Donthireddy Ayumi Hashimoto Alexandr Kapralov Andrew Amoscato Roberto Angelini Sima Patel Kevin Alicea-Torres David Weiner Maureen E. Murphy Judith Klein-Seetharaman Esteban Celis Valerian E. Kagan Dmitry I. Gabrilovich
author_facet	Filippo Veglia Vladimir A. Tyurin Dariush Mohammadyani Maria Blasi Elizabeth K. Duperret Laxminarasimha Donthireddy Ayumi Hashimoto Alexandr Kapralov Andrew Amoscato Roberto Angelini Sima Patel Kevin Alicea-Torres David Weiner Maureen E. Murphy Judith Klein-Seetharaman Esteban Celis Valerian E. Kagan Dmitry I. Gabrilovich
author_sort	Filippo Veglia
title	Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
title_short	Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
title_full	Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
title_fullStr	Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
title_full_unstemmed	Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
title_sort	lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/80f0969ac22343d0a493d691f1f910c0
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Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

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