Investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization

Due to the vital functions of bone tissue in the body, any change in its structure affects the balance of the body. Following a lesion, the body may be unable to repair it, and bone scaffolds may be implanted to stimulate bone cells and thus repair lost bone. This article aims to develop a scaffold...

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Autores principales:	Nazanin Baneshi, Bahareh Kamyab Moghadas, Adedotun Adetunla, Mohd Yusmiaidil Putera Mohd Yusof, Mohammad Dehghani, Amirsalar Khandan, Saeed Saber-Samandari, Davood Toghraie
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Bone scaffold Tissue engineering Biomaterial 3D printing Freeze-drying Mining engineering. Metallurgy TN1-997
Acceso en línea:	https://doaj.org/article/80f29318c383414cabc464a3f72255d4
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spelling	oai:doaj.org-article:80f29318c383414cabc464a3f72255d42021-11-20T05:06:32ZInvestigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization2238-785410.1016/j.jmrt.2021.10.107https://doaj.org/article/80f29318c383414cabc464a3f72255d42021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2238785421012436https://doaj.org/toc/2238-7854Due to the vital functions of bone tissue in the body, any change in its structure affects the balance of the body. Following a lesion, the body may be unable to repair it, and bone scaffolds may be implanted to stimulate bone cells and thus repair lost bone. This article aims to develop a scaffold with ideal properties that can be used to treat fractures and injuries. The technique used in this study is a hybrid of 3D printing and freeze-drying. Alginate (ALG), polyvinyl alcohol (PVA), and bioceramic-titanium nanoparticles were used to coat electroconductive polylactic acid (EC-PLA) using the freeze-drying method. The prepared samples were analyzed using a scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) for morphology functional group and phase characterizations. After coating the scaffolds with the freeze-drying method, the pore size was examined and correlated with the compressive strength values. For biological studies, a bioactivity test involving immersion of the samples in simulated body fluids (SBF) was performed for a specified period. The samples were then evaluated for water absorption, weight loss, and pH changes. Cell behavioral and antibacterial tests were performed to evaluate the growth of scaffolds in the body. Additionally, the compressive strength test results are incorporated into simulation and modeling analyses under static loading and micromechanical models. Finally, the circle-shaped scaffold containing titanium sample was chosen as a suitable scaffold due to its 78% porosity, 27% apatite formation, 75° wetting angle, 15% weight loss after 7 days, and 99% biocompatibility. Finally, the bio-nanocomposite scaffold can attach to the cell and then gradually degrade, preserving the implant's mechanical properties for the regeneration process.Nazanin BaneshiBahareh Kamyab MoghadasAdedotun AdetunlaMohd Yusmiaidil Putera Mohd YusofMohammad DehghaniAmirsalar KhandanSaeed Saber-SamandariDavood ToghraieElsevierarticleBone scaffoldTissue engineeringBiomaterial3D printingFreeze-dryingMining engineering. MetallurgyTN1-997ENJournal of Materials Research and Technology, Vol 15, Iss , Pp 5526-5539 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bone scaffold Tissue engineering Biomaterial 3D printing Freeze-drying Mining engineering. Metallurgy TN1-997
spellingShingle	Bone scaffold Tissue engineering Biomaterial 3D printing Freeze-drying Mining engineering. Metallurgy TN1-997 Nazanin Baneshi Bahareh Kamyab Moghadas Adedotun Adetunla Mohd Yusmiaidil Putera Mohd Yusof Mohammad Dehghani Amirsalar Khandan Saeed Saber-Samandari Davood Toghraie Investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization
description	Due to the vital functions of bone tissue in the body, any change in its structure affects the balance of the body. Following a lesion, the body may be unable to repair it, and bone scaffolds may be implanted to stimulate bone cells and thus repair lost bone. This article aims to develop a scaffold with ideal properties that can be used to treat fractures and injuries. The technique used in this study is a hybrid of 3D printing and freeze-drying. Alginate (ALG), polyvinyl alcohol (PVA), and bioceramic-titanium nanoparticles were used to coat electroconductive polylactic acid (EC-PLA) using the freeze-drying method. The prepared samples were analyzed using a scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) for morphology functional group and phase characterizations. After coating the scaffolds with the freeze-drying method, the pore size was examined and correlated with the compressive strength values. For biological studies, a bioactivity test involving immersion of the samples in simulated body fluids (SBF) was performed for a specified period. The samples were then evaluated for water absorption, weight loss, and pH changes. Cell behavioral and antibacterial tests were performed to evaluate the growth of scaffolds in the body. Additionally, the compressive strength test results are incorporated into simulation and modeling analyses under static loading and micromechanical models. Finally, the circle-shaped scaffold containing titanium sample was chosen as a suitable scaffold due to its 78% porosity, 27% apatite formation, 75° wetting angle, 15% weight loss after 7 days, and 99% biocompatibility. Finally, the bio-nanocomposite scaffold can attach to the cell and then gradually degrade, preserving the implant's mechanical properties for the regeneration process.
format	article
author	Nazanin Baneshi Bahareh Kamyab Moghadas Adedotun Adetunla Mohd Yusmiaidil Putera Mohd Yusof Mohammad Dehghani Amirsalar Khandan Saeed Saber-Samandari Davood Toghraie
author_facet	Nazanin Baneshi Bahareh Kamyab Moghadas Adedotun Adetunla Mohd Yusmiaidil Putera Mohd Yusof Mohammad Dehghani Amirsalar Khandan Saeed Saber-Samandari Davood Toghraie
author_sort	Nazanin Baneshi
title	Investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization
title_short	Investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization
title_full	Investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization
title_fullStr	Investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization
title_full_unstemmed	Investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization
title_sort	investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: fabrication, simulation and characterization
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/80f29318c383414cabc464a3f72255d4
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Investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization

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