Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.

H5N1 highly pathogenic avian influenza virus (HPAIV) infection has been reported in poultry and humans with expanding clade designations. Therefore, a vaccine that induces immunity against a broad spectrum of H5N1 viruses is preferable for pandemic preparedness. We established a second H5N1 vaccine...

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Autores principales:	Misako Nakayama, Shintaro Shichinohe, Yasushi Itoh, Hirohito Ishigaki, Mitsutaka Kitano, Masahiko Arikata, Van Loi Pham, Hideaki Ishida, Naoko Kitagawa, Masatoshi Okamatsu, Yoshihiro Sakoda, Takaya Ichikawa, Hideaki Tsuchiya, Shinichiro Nakamura, Quynh Mai Le, Mutsumi Ito, Yoshihiro Kawaoka, Hiroshi Kida, Kazumasa Ogasawara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/80f59a51de114539adb638a3ce35ca72
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spelling	oai:doaj.org-article:80f59a51de114539adb638a3ce35ca722021-11-18T08:40:42ZProtection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.1932-620310.1371/journal.pone.0082740https://doaj.org/article/80f59a51de114539adb638a3ce35ca722013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24376571/?tool=EBIhttps://doaj.org/toc/1932-6203H5N1 highly pathogenic avian influenza virus (HPAIV) infection has been reported in poultry and humans with expanding clade designations. Therefore, a vaccine that induces immunity against a broad spectrum of H5N1 viruses is preferable for pandemic preparedness. We established a second H5N1 vaccine candidate, A/duck/Hokkaido/Vac-3/2007 (Vac-3), in our virus library and examined the efficacy of inactivated whole particles of this strain against two clades of H5N1 HPAIV strains that caused severe morbidity in cynomolgus macaques. Virus propagation in vaccinated macaques infected with either of the H5N1 HPAIV strains was prevented compared with that in unvaccinated macaques. This vaccine also prevented propagation of a pandemic (H1N1) 2009 virus in macaques. In the vaccinated macaques, neutralization activity, which was mainly shown by anti-hemagglutinin antibody, against H5N1 HPAIVs in plasma was detected, but that against H1N1 virus was not detected. However, neuraminidase inhibition activity in plasma and T-lymphocyte responses in lymph nodes against H1N1 virus were detected. Therefore, cross-clade and heterosubtypic protective immunity in macaques consisted of humoral and cellular immunity induced by vaccination with Vac-3.Misako NakayamaShintaro ShichinoheYasushi ItohHirohito IshigakiMitsutaka KitanoMasahiko ArikataVan Loi PhamHideaki IshidaNaoko KitagawaMasatoshi OkamatsuYoshihiro SakodaTakaya IchikawaHideaki TsuchiyaShinichiro NakamuraQuynh Mai LeMutsumi ItoYoshihiro KawaokaHiroshi KidaKazumasa OgasawaraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e82740 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Misako Nakayama Shintaro Shichinohe Yasushi Itoh Hirohito Ishigaki Mitsutaka Kitano Masahiko Arikata Van Loi Pham Hideaki Ishida Naoko Kitagawa Masatoshi Okamatsu Yoshihiro Sakoda Takaya Ichikawa Hideaki Tsuchiya Shinichiro Nakamura Quynh Mai Le Mutsumi Ito Yoshihiro Kawaoka Hiroshi Kida Kazumasa Ogasawara Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.
description	H5N1 highly pathogenic avian influenza virus (HPAIV) infection has been reported in poultry and humans with expanding clade designations. Therefore, a vaccine that induces immunity against a broad spectrum of H5N1 viruses is preferable for pandemic preparedness. We established a second H5N1 vaccine candidate, A/duck/Hokkaido/Vac-3/2007 (Vac-3), in our virus library and examined the efficacy of inactivated whole particles of this strain against two clades of H5N1 HPAIV strains that caused severe morbidity in cynomolgus macaques. Virus propagation in vaccinated macaques infected with either of the H5N1 HPAIV strains was prevented compared with that in unvaccinated macaques. This vaccine also prevented propagation of a pandemic (H1N1) 2009 virus in macaques. In the vaccinated macaques, neutralization activity, which was mainly shown by anti-hemagglutinin antibody, against H5N1 HPAIVs in plasma was detected, but that against H1N1 virus was not detected. However, neuraminidase inhibition activity in plasma and T-lymphocyte responses in lymph nodes against H1N1 virus were detected. Therefore, cross-clade and heterosubtypic protective immunity in macaques consisted of humoral and cellular immunity induced by vaccination with Vac-3.
format	article
author	Misako Nakayama Shintaro Shichinohe Yasushi Itoh Hirohito Ishigaki Mitsutaka Kitano Masahiko Arikata Van Loi Pham Hideaki Ishida Naoko Kitagawa Masatoshi Okamatsu Yoshihiro Sakoda Takaya Ichikawa Hideaki Tsuchiya Shinichiro Nakamura Quynh Mai Le Mutsumi Ito Yoshihiro Kawaoka Hiroshi Kida Kazumasa Ogasawara
author_facet	Misako Nakayama Shintaro Shichinohe Yasushi Itoh Hirohito Ishigaki Mitsutaka Kitano Masahiko Arikata Van Loi Pham Hideaki Ishida Naoko Kitagawa Masatoshi Okamatsu Yoshihiro Sakoda Takaya Ichikawa Hideaki Tsuchiya Shinichiro Nakamura Quynh Mai Le Mutsumi Ito Yoshihiro Kawaoka Hiroshi Kida Kazumasa Ogasawara
author_sort	Misako Nakayama
title	Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.
title_short	Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.
title_full	Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.
title_fullStr	Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.
title_full_unstemmed	Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.
title_sort	protection against h5n1 highly pathogenic avian and pandemic (h1n1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated h5n1 whole particle vaccine.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/80f59a51de114539adb638a3ce35ca72
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Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.

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