Tumor-penetrating therapy for β5 integrin-rich pancreas cancer

The iRGD tumor-penetrating peptide can achieve tumor specific drug delivery but whether and how it can penetrate into desmoplastic tumors is unknown. Here, the authors show that β5 integrin expression on tumor cells, mediated by CAFs-derived TGF-β, is required for iRGD penetration into the desmoplas...

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Main Authors:	Tatiana Hurtado de Mendoza, Evangeline S. Mose, Gregory P. Botta, Gary B. Braun, Venkata R. Kotamraju, Randall P. French, Kodai Suzuki, Norio Miyamura, Tambet Teesalu, Erkki Ruoslahti, Andrew M. Lowy, Kazuki N. Sugahara
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/80f9f85745054067b544050e7b18b670
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spelling	oai:doaj.org-article:80f9f85745054067b544050e7b18b6702021-12-02T13:34:55ZTumor-penetrating therapy for β5 integrin-rich pancreas cancer10.1038/s41467-021-21858-12041-1723https://doaj.org/article/80f9f85745054067b544050e7b18b6702021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21858-1https://doaj.org/toc/2041-1723The iRGD tumor-penetrating peptide can achieve tumor specific drug delivery but whether and how it can penetrate into desmoplastic tumors is unknown. Here, the authors show that β5 integrin expression on tumor cells, mediated by CAFs-derived TGF-β, is required for iRGD penetration into the desmoplastic PDAC microenvironment and that iRGD-based combination therapy is effective in PDAC mouse models.Tatiana Hurtado de MendozaEvangeline S. MoseGregory P. BottaGary B. BraunVenkata R. KotamrajuRandall P. FrenchKodai SuzukiNorio MiyamuraTambet TeesaluErkki RuoslahtiAndrew M. LowyKazuki N. SugaharaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tatiana Hurtado de Mendoza Evangeline S. Mose Gregory P. Botta Gary B. Braun Venkata R. Kotamraju Randall P. French Kodai Suzuki Norio Miyamura Tambet Teesalu Erkki Ruoslahti Andrew M. Lowy Kazuki N. Sugahara Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
description	The iRGD tumor-penetrating peptide can achieve tumor specific drug delivery but whether and how it can penetrate into desmoplastic tumors is unknown. Here, the authors show that β5 integrin expression on tumor cells, mediated by CAFs-derived TGF-β, is required for iRGD penetration into the desmoplastic PDAC microenvironment and that iRGD-based combination therapy is effective in PDAC mouse models.
format	article
author	Tatiana Hurtado de Mendoza Evangeline S. Mose Gregory P. Botta Gary B. Braun Venkata R. Kotamraju Randall P. French Kodai Suzuki Norio Miyamura Tambet Teesalu Erkki Ruoslahti Andrew M. Lowy Kazuki N. Sugahara
author_facet	Tatiana Hurtado de Mendoza Evangeline S. Mose Gregory P. Botta Gary B. Braun Venkata R. Kotamraju Randall P. French Kodai Suzuki Norio Miyamura Tambet Teesalu Erkki Ruoslahti Andrew M. Lowy Kazuki N. Sugahara
author_sort	Tatiana Hurtado de Mendoza
title	Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
title_short	Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
title_full	Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
title_fullStr	Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
title_full_unstemmed	Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
title_sort	tumor-penetrating therapy for β5 integrin-rich pancreas cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/80f9f85745054067b544050e7b18b670
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Tumor-penetrating therapy for β5 integrin-rich pancreas cancer

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