Tumor-penetrating therapy for β5 integrin-rich pancreas cancer

Tumor-penetrating therapy for β5 integrin-rich pancreas cancer

The iRGD tumor-penetrating peptide can achieve tumor specific drug delivery but whether and how it can penetrate into desmoplastic tumors is unknown. Here, the authors show that β5 integrin expression on tumor cells, mediated by CAFs-derived TGF-β, is required for iRGD penetration into the desmoplas...

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Bibliographic Details
Main Authors: Tatiana Hurtado de Mendoza, Evangeline S. Mose, Gregory P. Botta, Gary B. Braun, Venkata R. Kotamraju, Randall P. French, Kodai Suzuki, Norio Miyamura, Tambet Teesalu, Erkki Ruoslahti, Andrew M. Lowy, Kazuki N. Sugahara
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/80f9f85745054067b544050e7b18b670
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https://doaj.org/article/80f9f85745054067b544050e7b18b670

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