Association Between Serum Human Epididymis Protein 4 Levels and Cardiovascular Events in Obese Patients with Breast Cancer

Li Wang,1 Nie Hu,1 Zhongjun Jiang,1 Ping Luo,1 Nian Yi,1 Yanhua Chen,2 Ning Zhou,2 Longfei Liu2 1Department of Breast Surgery, Nanhua Hospital, Nanhua University, Hengyang City, Hunan Province, 421002, People’s Republic of China; 2Department of General Surgery, Nanhua Hospital, Nanhua University, He...

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Autores principales:	Wang L, Hu N, Jiang Z, Luo P, Yi N, Chen Y, Zhou N, Liu L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	he4 breast cancer cardiovascular events obese prognostic value Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/80fc2cf5d405488e8b3bc713f52cc5b2
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spelling	oai:doaj.org-article:80fc2cf5d405488e8b3bc713f52cc5b22021-12-02T17:08:57ZAssociation Between Serum Human Epididymis Protein 4 Levels and Cardiovascular Events in Obese Patients with Breast Cancer1178-7007https://doaj.org/article/80fc2cf5d405488e8b3bc713f52cc5b22021-08-01T00:00:00Zhttps://www.dovepress.com/association-between-serum-human-epididymis-protein-4-levels-and-cardio-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Li Wang,1 Nie Hu,1 Zhongjun Jiang,1 Ping Luo,1 Nian Yi,1 Yanhua Chen,2 Ning Zhou,2 Longfei Liu2 1Department of Breast Surgery, Nanhua Hospital, Nanhua University, Hengyang City, Hunan Province, 421002, People’s Republic of China; 2Department of General Surgery, Nanhua Hospital, Nanhua University, Hengyang City, Hunan Province, 421002, People’s Republic of ChinaCorrespondence: Longfei LiuDepartment of General Surgery, Nanhua Hospital, Nanhua University, No. 336, Dongfeng South Road, Hengyang City, Hunan Province, 421002, People’s Republic of ChinaTel +86 0734-8399028Email liulongfei1977@aliyun.comBackground: Patients with cancer have a higher incidence of cardiovascular diseases (CVDs). We aimed to evaluate the relationship between serum human epididymal protein 4 (HE4) levels and cardiovascular events in obese patients with breast cancer.Methods: Serum HE4 levels in 316 obese patients with breast cancer were measured at baseline and then prospectively followed up for approximately 36 months. The prognostic value of serum HE4 for predicting cardiovascular events was analyzed by the Cox proportional hazard model.Results: Serum HE4 was significantly associated with CVD history after adjustment for confounding factors (OR= 1.50; 95% CI 1.23– 3.43; P= 0.038) using multivariable logistic regression analysis. The multivariable Cox proportional hazard analysis suggested that serum HE4 had an independent prognostic value for predicting cardiovascular events in patients with breast cancer (HR=2.21, 95% CI 1.60– 5.13, P< 0.001). Additionally, sensitivity analysis showed that the independent association still existed. Stratified analysis showed that this relationship was not affected by chemoradiotherapy.Conclusion: Serum HE4 is significantly related to cardiovascular events and poses good prognostic value for predicting cardiovascular events in obese patients with breast cancer. Serum HE4 may be a valuable indicator for the early detection of cardiovascular complications in obese patients with breast cancer.Keywords: human epididymis protein 4, radiotherapy, breast cancer, cardiovascular events, prognostic value, obeseWang LHu NJiang ZLuo PYi NChen YZhou NLiu LDove Medical Pressarticlehe4breast cancercardiovascular eventsobeseprognostic valueSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3703-3710 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	he4 breast cancer cardiovascular events obese prognostic value Specialties of internal medicine RC581-951
spellingShingle	he4 breast cancer cardiovascular events obese prognostic value Specialties of internal medicine RC581-951 Wang L Hu N Jiang Z Luo P Yi N Chen Y Zhou N Liu L Association Between Serum Human Epididymis Protein 4 Levels and Cardiovascular Events in Obese Patients with Breast Cancer
description	Li Wang,1 Nie Hu,1 Zhongjun Jiang,1 Ping Luo,1 Nian Yi,1 Yanhua Chen,2 Ning Zhou,2 Longfei Liu2 1Department of Breast Surgery, Nanhua Hospital, Nanhua University, Hengyang City, Hunan Province, 421002, People’s Republic of China; 2Department of General Surgery, Nanhua Hospital, Nanhua University, Hengyang City, Hunan Province, 421002, People’s Republic of ChinaCorrespondence: Longfei LiuDepartment of General Surgery, Nanhua Hospital, Nanhua University, No. 336, Dongfeng South Road, Hengyang City, Hunan Province, 421002, People’s Republic of ChinaTel +86 0734-8399028Email liulongfei1977@aliyun.comBackground: Patients with cancer have a higher incidence of cardiovascular diseases (CVDs). We aimed to evaluate the relationship between serum human epididymal protein 4 (HE4) levels and cardiovascular events in obese patients with breast cancer.Methods: Serum HE4 levels in 316 obese patients with breast cancer were measured at baseline and then prospectively followed up for approximately 36 months. The prognostic value of serum HE4 for predicting cardiovascular events was analyzed by the Cox proportional hazard model.Results: Serum HE4 was significantly associated with CVD history after adjustment for confounding factors (OR= 1.50; 95% CI 1.23– 3.43; P= 0.038) using multivariable logistic regression analysis. The multivariable Cox proportional hazard analysis suggested that serum HE4 had an independent prognostic value for predicting cardiovascular events in patients with breast cancer (HR=2.21, 95% CI 1.60– 5.13, P< 0.001). Additionally, sensitivity analysis showed that the independent association still existed. Stratified analysis showed that this relationship was not affected by chemoradiotherapy.Conclusion: Serum HE4 is significantly related to cardiovascular events and poses good prognostic value for predicting cardiovascular events in obese patients with breast cancer. Serum HE4 may be a valuable indicator for the early detection of cardiovascular complications in obese patients with breast cancer.Keywords: human epididymis protein 4, radiotherapy, breast cancer, cardiovascular events, prognostic value, obese
format	article
author	Wang L Hu N Jiang Z Luo P Yi N Chen Y Zhou N Liu L
author_facet	Wang L Hu N Jiang Z Luo P Yi N Chen Y Zhou N Liu L
author_sort	Wang L
title	Association Between Serum Human Epididymis Protein 4 Levels and Cardiovascular Events in Obese Patients with Breast Cancer
title_short	Association Between Serum Human Epididymis Protein 4 Levels and Cardiovascular Events in Obese Patients with Breast Cancer
title_full	Association Between Serum Human Epididymis Protein 4 Levels and Cardiovascular Events in Obese Patients with Breast Cancer
title_fullStr	Association Between Serum Human Epididymis Protein 4 Levels and Cardiovascular Events in Obese Patients with Breast Cancer
title_full_unstemmed	Association Between Serum Human Epididymis Protein 4 Levels and Cardiovascular Events in Obese Patients with Breast Cancer
title_sort	association between serum human epididymis protein 4 levels and cardiovascular events in obese patients with breast cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/80fc2cf5d405488e8b3bc713f52cc5b2
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Association Between Serum Human Epididymis Protein 4 Levels and Cardiovascular Events in Obese Patients with Breast Cancer

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