Back to the Future for Dermatophyte Genomics

ABSTRACT Dermatophytes are a uniquely pathogenic group of fungi that cause most common fungal infections globally. The major cause of athlete’s foot is Trichophyton rubrum, a pathogen of human skin. A recent paper in this journal reported the sequencing and analysis of five additional genome sequenc...

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Autores principales:	Zeyana S. Rivera, Liliana Losada, William C. Nierman
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/80fcaaef1da94e779f56664d68cfb3a3
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spelling	oai:doaj.org-article:80fcaaef1da94e779f56664d68cfb3a32021-11-15T15:39:11ZBack to the Future for Dermatophyte Genomics10.1128/mBio.00381-122150-7511https://doaj.org/article/80fcaaef1da94e779f56664d68cfb3a32012-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00381-12https://doaj.org/toc/2150-7511ABSTRACT Dermatophytes are a uniquely pathogenic group of fungi that cause most common fungal infections globally. The major cause of athlete’s foot is Trichophyton rubrum, a pathogen of human skin. A recent paper in this journal reported the sequencing and analysis of five additional genome sequences, including that of Trichophyton rubrum. These five join the existing two additional genome sequences to bring the total to seven dermatophyte genome sequences, a notable milestone in the study of these fungi. These additional genomes set the stage for future genome-supported studies on the biology, pathogenicity, and host specificity of this important group of pathogens. To predict how this future might play out, we review the history of Aspergillus genomics since the initial publication of the first three Aspergillus genome sequences in 2005, an event that stimulated important studies of the pathogenic Aspergillus species. From these 7 years of Aspergillus history, we offer some speculation on the future of dermatophyte studies supported by the genome sequences given the similarities, differences, and relative levels of support for studies in these two groups of fungi and the diseases they cause.Zeyana S. RiveraLiliana LosadaWilliam C. NiermanAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 6 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Zeyana S. Rivera Liliana Losada William C. Nierman Back to the Future for Dermatophyte Genomics
description	ABSTRACT Dermatophytes are a uniquely pathogenic group of fungi that cause most common fungal infections globally. The major cause of athlete’s foot is Trichophyton rubrum, a pathogen of human skin. A recent paper in this journal reported the sequencing and analysis of five additional genome sequences, including that of Trichophyton rubrum. These five join the existing two additional genome sequences to bring the total to seven dermatophyte genome sequences, a notable milestone in the study of these fungi. These additional genomes set the stage for future genome-supported studies on the biology, pathogenicity, and host specificity of this important group of pathogens. To predict how this future might play out, we review the history of Aspergillus genomics since the initial publication of the first three Aspergillus genome sequences in 2005, an event that stimulated important studies of the pathogenic Aspergillus species. From these 7 years of Aspergillus history, we offer some speculation on the future of dermatophyte studies supported by the genome sequences given the similarities, differences, and relative levels of support for studies in these two groups of fungi and the diseases they cause.
format	article
author	Zeyana S. Rivera Liliana Losada William C. Nierman
author_facet	Zeyana S. Rivera Liliana Losada William C. Nierman
author_sort	Zeyana S. Rivera
title	Back to the Future for Dermatophyte Genomics
title_short	Back to the Future for Dermatophyte Genomics
title_full	Back to the Future for Dermatophyte Genomics
title_fullStr	Back to the Future for Dermatophyte Genomics
title_full_unstemmed	Back to the Future for Dermatophyte Genomics
title_sort	back to the future for dermatophyte genomics
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/80fcaaef1da94e779f56664d68cfb3a3
work_keys_str_mv	AT zeyanasrivera backtothefuturefordermatophytegenomics AT lilianalosada backtothefuturefordermatophytegenomics AT williamcnierman backtothefuturefordermatophytegenomics
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Back to the Future for Dermatophyte Genomics

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