Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption

Cubilin and the transmembrane protein amnionless (AMN) form the endocytic receptor cubam that is essential for intestinal vitamin B12 uptake. Here the authors present the 2.3 Å crystal structure of AMN in complex with the amino-terminal region of cubilin and discuss cubam architecture and disease ca...

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Autores principales: Casper Larsen, Anders Etzerodt, Mette Madsen, Karsten Skjødt, Søren Kragh Moestrup, Christian Brix Folsted Andersen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/80fcc40c89f8413ba5eb477b1dfa5777
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spelling oai:doaj.org-article:80fcc40c89f8413ba5eb477b1dfa57772021-12-02T16:49:18ZStructural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption10.1038/s41467-018-07468-42041-1723https://doaj.org/article/80fcc40c89f8413ba5eb477b1dfa57772018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07468-4https://doaj.org/toc/2041-1723Cubilin and the transmembrane protein amnionless (AMN) form the endocytic receptor cubam that is essential for intestinal vitamin B12 uptake. Here the authors present the 2.3 Å crystal structure of AMN in complex with the amino-terminal region of cubilin and discuss cubam architecture and disease causing mutations.Casper LarsenAnders EtzerodtMette MadsenKarsten SkjødtSøren Kragh MoestrupChristian Brix Folsted AndersenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Casper Larsen
Anders Etzerodt
Mette Madsen
Karsten Skjødt
Søren Kragh Moestrup
Christian Brix Folsted Andersen
Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
description Cubilin and the transmembrane protein amnionless (AMN) form the endocytic receptor cubam that is essential for intestinal vitamin B12 uptake. Here the authors present the 2.3 Å crystal structure of AMN in complex with the amino-terminal region of cubilin and discuss cubam architecture and disease causing mutations.
format article
author Casper Larsen
Anders Etzerodt
Mette Madsen
Karsten Skjødt
Søren Kragh Moestrup
Christian Brix Folsted Andersen
author_facet Casper Larsen
Anders Etzerodt
Mette Madsen
Karsten Skjødt
Søren Kragh Moestrup
Christian Brix Folsted Andersen
author_sort Casper Larsen
title Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
title_short Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
title_full Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
title_fullStr Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
title_full_unstemmed Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
title_sort structural assembly of the megadalton-sized receptor for intestinal vitamin b12 uptake and kidney protein reabsorption
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/80fcc40c89f8413ba5eb477b1dfa5777
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